苯巴比妥单一用药治疗农村癫痫患者疗效分析

发布时间：2018-10-10 18:44

【摘要】：目的评价2011~2015年哈尔滨市农村地区苯巴比妥单一用药治疗管理癫痫患者的效果。方法惊厥型癫痫病患者进行免费苯巴比妥单一用药治疗和随访管理,评价分析药物疗效、不良反应和患者依从性等指标。通过Epi Data 3.1软件录入数据,计量资料采用t检验,计数资料用χ~2,等级资料用H检验。结果癫痫病患者随访5年治疗有效率为68.8%,3~5年恶化率呈下降趋势,不同年份苯巴比妥疗效差异有统计学意义(χ~2=226.27,P=0.000)。癫痫患者服用苯巴比妥后发生共济失调、多动及皮疹等不良反应随时间变化呈下降趋势,癫痫患者治疗1~5年不良反应情况差异无统计学意义(χ~2=23.79,P=0.690)。随访到3年时不存在自我感觉更差的患者,不同年份癫痫患者自我感觉身体状况、精神状况或劳动学习能力比较差异有统计学意义(χ~2=85.86,P=0.000)。癫痫患者5年失访率为24.10%,拒绝服药是退组的主要原因。结论苯巴比妥单一用药治疗农村癫痫病患者取得良好的治疗效果,在农村地区推广并进行规范化管理是切实可行的。
[Abstract]:Objective to evaluate the efficacy of phenobarbital in the management of epilepsy patients in rural areas of Harbin from 2011 to 2015. Methods patients with epileptic seizures were treated with free phenobarbital alone and followed up. The efficacy, adverse reactions and compliance of patients were evaluated and analyzed. Data were inputted by Epi Data 3.1 software. T test was used for measuring data, 蠂 ~ 2 for counting data and H test for grade data. Results the effective rate of treatment was 68.8% and 3- 5 years, and the difference of phenobarbital effect in different years was statistically significant (蠂 ~ 2 ~ 226.27 ~ P ~ (0.000). After taking phenobarbital, the adverse reactions such as ataxia, hyperactivity and rash decreased with time in epileptic patients. There was no significant difference in adverse reactions between 1 ~ 5 years after treatment (蠂 ~ 2 + 23.79 / P0.690). After 3 years of follow-up, there were no patients with worse self-feeling. There were significant differences in self-feeling physical condition, mental status or learning ability between epileptic patients in different years (蠂 ~ 2 ~ (85.86) P ~ (0.000). The 5-year lost visit rate of epileptic patients was 24.10%, and the main reason for the withdrawal was to refuse to take medicine. Conclusion phenobarbital alone is effective in the treatment of epilepsy in rural areas.
【作者单位】：黑龙江省哈尔滨市疾病预防控制中心慢病所;黑龙江省疾病预防控制中心慢病所;
【分类号】：R742.1

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