丁苯酞对帕金森病患者氧化应激及质子磁共振波谱的影响

发布时间：2018-10-11 10:28

【摘要】：目的探讨丁苯酞治疗帕金森病(PD)的效果及对氧化应激指标、核磁共振波谱的影响。方法选取初次来该院住院治疗的PD患者64例,对照组32例给予常规美多芭治疗,研究组32例在对照组的基础上给予丁苯酞治疗,对两组患者行统一PD评定量表(UPDRS)评测、磁共振波谱检查,检测患者血中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、过氧化氢酶(CAT)、丙二醛(MDA)水平。结果两组治疗后UPDRS评分均降低,且研究组低于对照组(P0.05);与对照组比较,研究组治疗后SOD、GSH-PX、CAT水平均升高,MDA水平降低,磁共振波谱N-乙酰天门冬氨酸(NAA)/肌酸(Cr)及胆碱复合物(Cho)/Cr升高(P0.05)。结论在口服美多芭治疗基础上联合应用丁苯酞对PD的治疗有更好的效果,其效果可能与丁苯酞调控抗氧化酶能力有关。
[Abstract]:Objective to investigate the effect of butyphthalide on Parkinson's disease (PD) and its effect on oxidative stress and nuclear magnetic resonance spectroscopy (NMR). Methods Sixty-four patients with PD, 32 patients in the control group and 32 patients in the study group were treated with butyphthalide on the basis of the control group. The patients in the two groups were evaluated by (UPDRS) with the Unified PD rating scale (UPDRS). The levels of superoxide dismutase (SOD),) glutathione peroxidase (GSH-PX) and catalase (CAT), malondialdehyde (MDA) were detected by magnetic resonance spectroscopy. Results after treatment, the UPDRS scores in both groups were lower than those in the control group (P0.05). Compared with the control group, the levels of SOD,GSH-PX,CAT and MDA in the study group were all increased, and the (NAA) / creatine (Cr) and the choline complex (Cho) / Cr were increased in the magnetic resonance spectrum (P0.05). Conclusion the combination of butyphthalide and butyrophthalide has a better effect on the treatment of PD on the basis of oral medopa therapy, and its effect may be related to the ability of butyphthalide to regulate antioxidant enzymes.
【作者单位】：潍坊市人民医院;首都医科大学宣武医院检验科;
【基金】：潍坊市科学技术发展计划项目(201102011)
【分类号】：R742.5

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