南宁市帕金森病用药情况的横断面调查及相关因素分析
发布时间：2018-10-17 18:55
【摘要】：目的本文旨在了解南宁市帕金森病患者用药情况,分析其影响因素,与国内外其他地区用药情况进行比较,拟提出促使帕金森病患者合理用药的相关对策和建议。 方法对2013年7月至2013年11月就诊于南宁市各大医院神经内科的临床确诊的228例帕金森病患者进行当前用药情况的调查,按照研究者所在医院的药品价格计算患者每月药费情况,进行一般资料问卷调查,并对全部患者进行采用改良Hoehn-Yahr分级量表(Modified Hoehn and Yahr stage, H-Y)和统一帕金森病评分量表(Unified Parkinson's Disease Rating Scale, UPDRS)评估病情程度,利用蒙特利尔认知评价量表(Montreal Cognitive Assessment, CoMA)评估患者认知程度。 结果228例患者中,南宁市地区有126例,南宁以外的县市有102例；男性有152例(66.67%),女性有76例(33.33%)；有216例(94.73%)患者应用了左旋多巴制剂(多巴丝肼或卡左双多巴),有107例(46.92%)患者使用了多巴胺受体激动剂(Dopamine agonist, DR)(吡贝地尔或普拉克索),其中多巴丝肼168例(73.68%),卡左双多巴48例(21.05%),吡贝地尔89例(39.35%),普拉克索18例(7.89%),苯海索114例(50.00%),金刚烷胺86例(37.72%),司来吉兰6例(2.63%),恩他卡朋2例(0.88%)。H-Y分级Ⅰ-Ⅱ级患者南宁市市区患者的月均费用为168.20士62.10元,外地患者的月均费用为158.20士46.72元,两组间比较无明显差异(P0.05),Ⅲ级者南宁市市区患者的月均费用为288.50士262.19元,外地患者的月均费用为240.41士239.41元,两组间比较无明显差异(P0.05),Ⅳ-Ⅴ级者南宁市市区患者的月均费用为411.76士301.65元,外地患者的月均费用为408.68士374.15元,两组间比较无明显差异(P0.05)。单因素分析及元Logistic多回归分析结果显示,患者的病程、文化程度、对疾病的认知程度等因素对患者用药情况的影响有统计学意义。 结论南宁各区与南宁各县的PD治疗治疗药物基本相似,月均费用比较无明显统计学差异,患者认知程度是影响患者用药的主要因素。而国内多巴胺受体激动剂的使用还不如国外普及程度。为了提高PD患者规范化治疗的水平、减少经济负担、改善患者生活质量,需要PD患者、医务工作者、政府部门的共同努力。
[Abstract]:Objective the purpose of this paper is to understand the situation of drug use in patients with Parkinson's disease in Nanning, analyze its influencing factors, compare it with other regions at home and abroad, and propose relevant countermeasures and suggestions to promote the rational use of drugs in patients with Parkinson's disease. Methods from July 2013 to November 2013, 228 patients with Parkinson's disease who were clinically diagnosed in the Department of Neurology, Nanning City, were investigated. The monthly drug cost of the patients was calculated according to the drug price in the hospital. General data were investigated and the patients were assessed with modified Hoehn-Yahr scale (Modified Hoehn and Yahr stage, H-Y) and Unified Parkinson's Disease scale (Unified Parkinson's Disease Rating Scale, UPDRS). The cognitive degree of patients was evaluated by Montreal Cognitive Assessment scale (Montreal Cognitive Assessment, CoMA). Results among 228 patients, 126 were in Nanning and 102 were in counties other than Nanning, 152 (66.67%) were male and 76 (33.33%) were female. 216 patients (94.73%) were treated with levodopa (dobutazid or carbozodopa) and 107 patients (46.92%) with dopamine receptor agonist (Dopamine agonist, DR) (pipedil or Praquisole. 48 cases (21.05%), 89 cases (39.35%), 89 cases (39.35%), 18 cases (7.89%), 114 cases (50.00%), 86 cases (37.72%), 86 cases (37.72%), 6 cases (2.63%), 2 cases (0.88%), respectively. The average monthly cost of non-local patients was 158.20 卤46.72 yuan, and there was no significant difference between the two groups (P0.05). The average monthly cost of Nanning patients in grade 鈪，
本文编号：2277640
[Abstract]:Objective the purpose of this paper is to understand the situation of drug use in patients with Parkinson's disease in Nanning, analyze its influencing factors, compare it with other regions at home and abroad, and propose relevant countermeasures and suggestions to promote the rational use of drugs in patients with Parkinson's disease. Methods from July 2013 to November 2013, 228 patients with Parkinson's disease who were clinically diagnosed in the Department of Neurology, Nanning City, were investigated. The monthly drug cost of the patients was calculated according to the drug price in the hospital. General data were investigated and the patients were assessed with modified Hoehn-Yahr scale (Modified Hoehn and Yahr stage, H-Y) and Unified Parkinson's Disease scale (Unified Parkinson's Disease Rating Scale, UPDRS). The cognitive degree of patients was evaluated by Montreal Cognitive Assessment scale (Montreal Cognitive Assessment, CoMA). Results among 228 patients, 126 were in Nanning and 102 were in counties other than Nanning, 152 (66.67%) were male and 76 (33.33%) were female. 216 patients (94.73%) were treated with levodopa (dobutazid or carbozodopa) and 107 patients (46.92%) with dopamine receptor agonist (Dopamine agonist, DR) (pipedil or Praquisole. 48 cases (21.05%), 89 cases (39.35%), 89 cases (39.35%), 18 cases (7.89%), 114 cases (50.00%), 86 cases (37.72%), 86 cases (37.72%), 6 cases (2.63%), 2 cases (0.88%), respectively. The average monthly cost of non-local patients was 158.20 卤46.72 yuan, and there was no significant difference between the two groups (P0.05). The average monthly cost of Nanning patients in grade 鈪，
本文编号：2277640
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