骨膜蛋白在不同级别脑膜瘤中的表达及其临床意义
发布时间：2018-10-19 13:03
【摘要】：目的探索骨膜蛋白在不同级别脑膜瘤中表达及其关系。方法回顾性分析175例凸面型脑膜瘤患者的资料。依据WHO脑膜瘤分级,对各组标本进行骨膜蛋白和Ki-67免疫组织化学检测和蛋白免疫印迹检测。随访并对比不同表达水平脑膜瘤术后患者的生存时间、复发率和无进展生存时间。结果不同WHO级别脑膜瘤中Ki-67的表达差异有统计学意义(P0.001),并且与WHO脑膜瘤的级别呈正相关(r=0.673,P0.001)。116例(66.3%)脑膜瘤中骨膜蛋白免疫组化结果阴性/弱阳性,不同WHO级别脑膜瘤中骨膜蛋白的表达差异有统计学意义(P0.001)并且与WHO级别呈正相关(r=0.742,P0.001)。脑膜瘤中Ki-67与骨膜蛋白的表达呈正相关(r=0.513,P0.001)。Ki-67和骨膜蛋白在WHOⅠ级与非WHOⅠ级脑膜瘤中表达差异有统计学意义(P0.001)。Ki-67和骨膜蛋白不同的表达水平脑膜瘤术后患者的复发率、无进展生存期率以及总体生存时间差异有统计学意义(P0.001)。结论骨膜蛋白在脑膜瘤间质中表达,与Ki-67可能作为脑膜瘤级别和预后的标志物。
[Abstract]:Objective to explore the expression of periosteal protein in different grades of meningiomas and its relationship. Methods the data of 175 patients with convex meningioma were retrospectively analyzed. According to the grade of WHO meningioma, periosteal protein and Ki-67 were detected by immunohistochemistry and Western blotting. The survival time, recurrence rate and progressive survival time of patients with meningioma with different expression levels were followed up and compared. Results the expression of Ki-67 in meningiomas of different WHO grades was significantly different (P0. 001), and positively correlated with the grade of WHO meningiomas (r: 0. 673, P0. 001). In 116 cases (66. 3%) of meningiomas, the expression of periosteal protein was negative or weakly positive. The expression of periosteal protein in meningiomas of different WHO grades was significantly different (P0. 001) and positively correlated with WHO grade (r = 0. 742, P0. 001). There was a positive correlation between the expression of Ki-67 and periosteal protein in meningiomas (r: 0.513 / P0.001). The expression of Ki-67 and periosteal protein in WHO 鈪，
本文编号：2281195
[Abstract]:Objective to explore the expression of periosteal protein in different grades of meningiomas and its relationship. Methods the data of 175 patients with convex meningioma were retrospectively analyzed. According to the grade of WHO meningioma, periosteal protein and Ki-67 were detected by immunohistochemistry and Western blotting. The survival time, recurrence rate and progressive survival time of patients with meningioma with different expression levels were followed up and compared. Results the expression of Ki-67 in meningiomas of different WHO grades was significantly different (P0. 001), and positively correlated with the grade of WHO meningiomas (r: 0. 673, P0. 001). In 116 cases (66. 3%) of meningiomas, the expression of periosteal protein was negative or weakly positive. The expression of periosteal protein in meningiomas of different WHO grades was significantly different (P0. 001) and positively correlated with WHO grade (r = 0. 742, P0. 001). There was a positive correlation between the expression of Ki-67 and periosteal protein in meningiomas (r: 0.513 / P0.001). The expression of Ki-67 and periosteal protein in WHO 鈪，
本文编号：2281195
本文链接：https://www.wllwen.com/yixuelunwen/shenjingyixue/2281195.html
最近更新
教材专著
