老年脑梗死患者外周血调节性T细胞水平及其与缺血性脑损伤和颈动脉粥样硬化严重程度的相关性

发布时间：2018-10-25 09:39

【摘要】：目的探讨老年动脉粥样硬化性脑梗死患者外周血调节性T细胞水平及其与缺血性脑损伤和颈动脉粥样硬化严重程度的相关性。方法选择老年动脉粥样硬化性脑梗死患者120例作为梗死组和同期体检的老年健康者120例作为对照组,梗死组根据梗死时间分为梗死组1 d、梗死组3 d、梗死组7 d;根据神经功能缺损程度分为轻度组、中度组和重度组;根据梗死灶大小分为小梗死灶组、中梗死灶组、大梗死灶组;根据颈动脉粥样硬化程度分为颈动脉内膜增厚组、颈动脉斑块组、颈动脉狭窄组。测定患者外周血CD4~+CD25~+调节性T细胞百分比和白细胞、中性粒细胞含量。结果梗死组外周血调节性T细胞水平明显低于对照组(P0.05)。梗死组1 d外周血调节性T细胞水平明显低于对照组(P0.05),梗死组3 d与对照组比较无差异(P0.05),梗死组7 d明显高于对照组(P0.05);梗死组1 d白细胞和中性粒细胞高于对照组(P0.05),梗死组3 d白细胞高于对照组(P0.05),梗死组3 d中性粒细胞和对照组比较无差异(P0.05),梗死组7 d白细胞和中性粒细胞和对照组比较无差异(P0.05)。重度组外周血调节性T细胞水平低于轻度组和中度组(P0.05),中度组外周血调节性T细胞水平低于轻度组(P0.05)。大梗死灶组外周血调节性T细胞水平高于小梗死灶组和中梗死灶组(P0.05),中梗死灶组外周血调节性T细胞水平低于小梗死灶组(P0.05)。颈动脉狭窄组外周血调节性T细胞水平低于颈动脉内膜增厚组和颈动脉斑块组(P0.05),颈动脉斑块组外周血调节性T细胞水平低于颈动脉内膜增厚组(P0.05)。结论老年动脉粥样硬化性脑梗死患者外周血调节性T细胞水平降低,外周血调节性T细胞水平与缺血性脑损伤和颈动脉粥样硬化严重程度关系密切。
[Abstract]:Objective to investigate the level of regulatory T cells in peripheral blood of elderly patients with atherosclerotic cerebral infarction (ACI) and its correlation with ischemic brain injury and severity of carotid atherosclerosis. Methods 120 elderly patients with atherosclerotic cerebral infarction were selected as infarct group and 120 healthy subjects as control group. According to the time of infarction, the infarct group was divided into three groups: one day, three days and seven days, according to the degree of neurological impairment, they were divided into three groups: mild group, moderate group and severe group, small infarction group, middle infarction group and large infarction group according to the size of infarct. According to the degree of carotid atherosclerosis, carotid intima thickening group, carotid plaque group, carotid stenosis group. The percentage of CD4~ CD25~ regulatory T cells and the contents of leukocytes and neutrophils in peripheral blood were measured. Results the level of regulatory T cells in the infarct group was significantly lower than that in the control group (P 0.05). The level of peripheral blood regulatory T cells in the infarction group was significantly lower than that in the control group on day 1 (P0.05), but there was no difference between the infarction group and the control group on the 3rd day (P0.05). The leukocytes in the infarction group were significantly higher than those in the control group (P0.05). There was no significant difference in neutrophils between the infarct group and the control group (P0.05), but there was no difference between the infarct group and the control group on the 7th day (P0.05). The level of peripheral blood regulatory T cells in severe group was lower than that in mild group and moderate group (P0.05), and the level of regulatory T cell in moderate group was lower than that in mild group (P0.05). The level of regulatory T cells in large infarction group was higher than that in small infarction group and middle infarct group (P0.05), while the level of regulatory T cell in middle infarct group was lower than that in small infarct group (P0.05). The level of peripheral blood regulatory T cells in carotid artery stenosis group was lower than that in carotid intimal thickening group and carotid plaque group (P0.05), and the level of peripheral blood regulatory T cell in carotid artery plaque group was lower than that in carotid intimal thickening group (P0.05). Conclusion the level of regulatory T cells in peripheral blood of aged patients with atherosclerotic cerebral infarction is lower than that of control T cells in peripheral blood. The level of regulatory T cells in peripheral blood is closely related to ischemic brain injury and carotid atherosclerosis.
【作者单位】：临海市第二人民医院神经内科;
【分类号】：R743.33

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