体液MicroRNAs在人脑胶质瘤中的诊断价值的Meta分析

发布时间：2018-11-11 18:08

【摘要】：目的:应用meta分析这一统计学方法综合评价体液micro RNAs在人脑胶质瘤中的诊断价值,为临床研究提供参考依据。方法:利用计算机全面检索Pub Med/Medline、Web of Science、Cochrane、Library、Google scholar等数据库,按照纳入与排除标准收集从各数据库建库至2016年12月发表的关于体液micro RNAs在人脑胶质瘤中的诊断的文献,应用stata12.0软件和Meta-disc1.4进行Meta分析。结果:共9篇文献包含10项关于体液micro RNAs在人脑胶质瘤中的诊断价值的研究纳入本次分析,共1394例研究对象。Meta分析结果显示,体液micro RNAs诊断胶质瘤的合并敏感度和合并特异性分别为0.84(95%CI:0.74~0.90)和0.88(95%CI:0.81~0.92),合并诊断阳性似然比和阴性似然比分别为6.98(95%CI:4.48~10.88)和0.18(95%CI:0.11~0.30),合并诊断比值比为38.20(95%CI:18.69~78.09)。总受试者工作特征曲线下面积为0.93,Q*值为0.86。结论:体液mi RNA检测具有创伤小、操作方便简单及可行动态检测等优点,在胶质瘤的诊断方面有较高的诊断价值,着着良好的应用前景。而样本类型是导致异质性的主要来源,体液mi RNA在临床中应用于胶质瘤的诊断仍需进行大量的研究。
[Abstract]:Objective: to evaluate the diagnostic value of humoral micro RNAs in human glioma by meta analysis. Methods: Pub Med/Medline,Web of Science,Cochrane,Library,Google scholar and other databases were searched by computer. According to the inclusion and exclusion criteria, the literature on the diagnosis of humoral micro RNAs in human glioma was collected from the establishment of each database to December 2016. Stata12.0 software and Meta-disc1.4 were used for Meta analysis. Results: ten studies on the diagnostic value of humoral micro RNAs in human glioma were included in this study. 1394 subjects were included in the study. The results of Meta analysis showed that, The combined sensitivity and specificity of humoral micro RNAs in the diagnosis of gliomas were 0.84 (95%CI:0.74~0.90) and 0.88 (95%CI:0.81~0.92), respectively. The positive likelihood ratio and negative likelihood ratio of combined diagnosis were 6.98 (95%CI:4.48~10.88) and 0.18 (95%CI:0.11~0.30), respectively. The ratio of combined diagnosis was 38.20 (95%CI:18.69~78.09). The area under the operating characteristic curve of the total subjects was 0.93 and the Q* value was 0.86. Conclusion: humoral mi RNA has the advantages of less trauma, simple operation and feasible dynamic detection. It has a high diagnostic value in the diagnosis of glioma and has a good application prospect. The sample type is the main source of heterogeneity. The clinical application of humoral mi RNA in the diagnosis of glioma still needs a lot of research.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R739.41

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