介入再通治疗非急性期基底动脉闭塞的中长期随访研究

发布时间：2018-11-12 07:03

【摘要】：目的:评价介入再通治疗非急性期基底动脉闭塞的中长期临床疗效。方法:收集2010年2月—2012年4月在我中心行介入再通治疗的闭塞超过24 h的非急性期基底动脉闭塞患者12例。记录围手术期并发症、随访期间短暂性脑缺血发作及卒中发生情况,使用非参数秩和检验比较手术前后及随访期间的改良Rankin量表(m RS)评分变化情况。结果:12例患者中有11例闭塞动脉(91.7%)成功开通。围手术期并发症发生2例,导致患者病情加重。8例患者获得影像学随访,中位随访时间12(6~30)个月,再狭窄2例,均为症状性。12例患者获得临床随访,中位随访时间51.5(0.5~73)个月,再发同侧性卒中2例,同侧性短暂性脑缺血发作1例。存活患者中,术后1周的m RS评分低于术前,术后3个月的m RS评分低于术后1周,差异均有统计学意义(P0.05)。结论:介入再通治疗非急性期基底动脉闭塞可在中远期预防再发缺血事件的发生,同时术后3月内患者的残疾功能改善明显,但再狭窄问题值得进一步关注。
[Abstract]:Objective: to evaluate the long-term clinical effect of interventional recanalization for non-acute basilar artery occlusion. Methods: from February 2010 to April 2012, 12 patients with non-acute basilar artery occlusion who received interventional recanalization therapy for more than 24 hours were collected. Perioperative complications, transient ischemic attack and stroke during follow-up were recorded. The changes of (m RS) score of modified Rankin scale before and after operation were compared with nonparametric rank sum test. Results: 11 out of 12 patients (91.7%) were successfully opened. There were 2 cases of perioperative complications, which resulted in the exacerbation of the patient's condition. The median follow-up time was 12 (630) months, and the restenosis was 2 cases, all of which were symptomatic. 12 patients were followed up clinically. The median follow-up time was 51.5 (0.5 卤73) months, with 2 cases of ipsilateral stroke and 1 case of ipsilateral transient ischemic attack. In the survival patients, the m RS score at 1 week after operation was lower than that before operation, and the m RS score at 3 months after operation was lower than that at 1 week after operation, the difference was statistically significant (P0.05). Conclusion: interventional recanalization of non-acute basilar artery occlusion can prevent recurrent ischemic events in the medium and long term, and the disability function of the patients can be improved significantly within 3 months after operation, but the restenosis should be paid more attention to.
【作者单位】：郑州大学人民医院介入科脑血管病区河南省人民医院国家高级卒中中心河南省介入治疗中心;
【基金】：河南省重点科技攻关项目(152102310416、162102310268) 河南省卫生科技攻关项目(201403191)
【分类号】：R743

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