强化训练结合预防性抗抑郁治疗对脑卒中患者的运动功能及抑郁状态的影响

发布时间：2018-11-17 14:03

【摘要】：目的:观察强化训练与预防性抗抑郁治疗对脑卒中患者的运动功能及抑郁状态的影响方法:采用随机数字表将45例脑卒中患者(均未诊断卒中后抑郁)分为单纯治疗组、强化训练组以及强化训练+预防性抗抑郁治疗组,每组各15例。3组患者皆给予常规脑卒中药物治疗及康复训练,强化训练组在此基础上每日增加1次运动功能训练。强化训练+预防性抗抑郁治疗组在在每日增加1次运动功能训练的同时,进一步给予预防性抗抑郁药物治疗。分别于治疗前、治疗2周后以及治疗4周后采集改良Barthel指数评定量表(MBI)、Fugl-Meyer运动功能评分(FMA)、抑郁自评量表(Self-rating depression scale,SDS)对患者的运动功能、生活自理能力、抑郁状态进行评估。结果:治疗前,三组患者在Barthel、FMA和抑郁指数三方面均无显著差异,治疗后强化训练组与强化训练+预防性抗抑郁治疗组分别比较单纯治疗组的Barthel指数及FMA评分均有显著差异,2组的ADL和FMA评分均高于单纯治疗组(P0.05)。强化训练+预防性抗抑郁治疗组与强化训练组相比,其Barthel指数、FMA评分差异没有统计学意义。三组的SDS评分在三组组间与治疗前后(组内)对比均无符合统计学意义。结论:强化运动训练治疗能有效改善脑卒中患者的整体预后表现,提高临床康复效果。接受预防性抗抑郁治疗患者的运动功能恢复以及对卒中后抑郁的发病率的影响与未接受预防性抗抑郁治疗的患者相比差异无统计学意义。本实验的患者在实验前后均未出现卒中后抑郁症,考虑此次实验存在样本量少、观察的时间较短等因素,目前尚不能得出预防性抗抑郁治疗无效的结论。
[Abstract]:Objective: to observe the effect of intensive training and prophylactic antidepressant therapy on motor function and depression state of stroke patients. Intensive training group and preventive antidepressant treatment group, 15 cases in each group. 3 groups of patients were given routine stroke drug treatment and rehabilitation training, intensive training group on the basis of daily exercise function training. Intensive training preventive antidepressant treatment group was treated with prophylactic antidepressant while increasing exercise function training once a day. Before, 2 weeks and 4 weeks after treatment, the motor function scores of modified Barthel index rating scale (MBI), Fugl-Meyer), motor function scale (FMA),) and self-rating depression scale (Self-rating depression scale,SDS) were collected to evaluate the motor function of the patients. Self-care ability and depression were evaluated. Results: before treatment, there was no significant difference in Barthel,FMA and depressive index among the three groups. There were significant differences in Barthel index and FMA score between the intensive training group and the preventive antidepressant group after treatment. The ADL and FMA scores in both groups were higher than those in the control group (P 0.05). There was no significant difference in Barthel index and FMA score between intensive training preventive antidepressant therapy group and intensive training group. The SDS scores of the three groups were not statistically significant between the three groups and before and after treatment. Conclusion: intensive exercise training can effectively improve the overall prognosis of stroke patients and improve the clinical rehabilitation effect. There was no significant difference in the recovery of motor function and the incidence of post-stroke depression in patients receiving prophylactic antidepressant therapy as compared with those who did not receive preventive antidepressant therapy. There was no post-stroke depression in the patients before and after the experiment. Considering the small sample size and short observation time, it is not possible to draw the conclusion that preventive antidepressant treatment is ineffective.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

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