阿司匹林与立普妥联合口服对不同类型颈动脉斑块的治疗效果

发布时间：2018-11-18 07:50

【摘要】：目的观察阿司匹林与阿托伐他汀钙片(立普妥)联合口服对不同类型颈动脉斑块的治疗效果。方法颈动脉斑块患者291例,联合口服拜阿司匹林肠溶片(100 mg/d)和立普妥(20 mg/晚),同时进行降血压、降血糖等治疗。治疗前、治疗6个月及12个月时分别进行彩色多普勒超声检查,观察患者双侧颈动脉斑块类型、大小变化。结果 291例患者中,治疗前彩色多普勒超声检查确诊为软斑146例、混合性斑块68例、硬斑77例;治疗6个月时,软斑100例、混合性斑块107例、硬斑84例;治疗12个月时,软斑4例、混合性斑块93例、硬斑177例、斑块完全消失17例;治疗6个月时与治疗前相比,P0.01;治疗12个月时与治疗6个月时相比,P0.01。治疗6个月时及12个月时,软斑患者、混合性斑块患者的斑块明显缩小,与治疗前相比,P均0.01,但硬斑斑块大小变化不明显(P0.05)。结论阿司匹林与立普妥联合口服治疗颈动脉斑块,软斑和混合性斑块的大小明显缩小,且能稳定斑块。对硬斑患者,要慎重决定是否给予药物治疗。
[Abstract]:Objective to observe the therapeutic effect of aspirin combined with Atto vastatin calcium tablets (Lipitor) on different types of carotid plaque. Methods 291 patients with carotid plaque were treated with oral aspirin enteric-coated tablets (100 mg/d) and Lipitor (20 mg/ late). Color Doppler ultrasonography was performed at 6 and 12 months before treatment to observe the type and size of carotid plaques. Results among 291 patients, 146 cases were diagnosed as soft plaque, 68 cases as mixed plaque, 77 cases as hard spot, 100 cases as soft plaque, 107 cases as mixed plaque, 84 cases as hard spot at 6 months after treatment. At 12 months, soft plaque was found in 4 cases, mixed plaque in 93 cases, hard plaque in 177 cases, and plaque disappeared completely in 17 cases; at 6 months after treatment, compared with that before treatment, P 0.01; 12 months after treatment, compared with 6 months, P 0.01. After 6 months and 12 months of treatment, the plaque size of soft spot patients and mixed plaque patients was significantly smaller than that of pre-treatment (P < 0.01), but the size of hard spots did not change significantly (P0.05). Conclusion Aspirin combined with Lipitor in the treatment of carotid plaque, soft plaque and mixed plaque can significantly reduce the size of plaque, and can stabilize plaque. For hard spot patients, it is necessary to carefully decide whether to give drug treatment.
【作者单位】：赣南医学院第一附属医院;
【基金】：江西省赣州市指导性科技计划项目(GZ2014ZSF054)
【分类号】：R743.3

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