颞叶癫痫患者海马CA3和内嗅皮层网络的癫痫尖波对theta节律抑制作用的量化评估

发布时间：2018-11-27 17:22

【摘要】：海马CA3和内嗅皮层(entorhinal cortex,EC)网络是海马认知功能和颞叶癫痫研究的关键回路之一,尖波对海马网络theta(4~8 Hz)节律抑制作用的研究有利于揭示癫痫对认知功能影响的机制。以往,在网络层面上,该抑制作用常借助脑片来实现定量评估。本文旨在建立依赖于脑深度局部场电位评估癫痫尖波对theta节律抑制作用的方法。从4位术前处于快速眼球运动(rapid eyes movement,REM)睡眠下的颞叶癫痫患者皮质电极记录中择取发作间期有散发性尖波(sporadic spikes,SSs)脑电和两个相邻SSs间无尖波暂态期脑电,尖波分别只在CA3、只在EC、或在CA3和EC同步出现,应用Gabor小波和Hilbert变换计算尖波前后和无尖波暂态期theta能量,并计算无尖波暂态期theta节律的断裂程度。结果显示:(1)尖波可瞬时降低theta能量,CA3和EC同步尖波时下降最为剧烈,抑制作用最强;(2)无尖波暂态期theta能量下降,出现theta节律消失,造成节律断裂,表明抑制作用在持续,且断裂程度与尖波附近抑制作用一致;(3)3例患者无尖波暂态期theta能量水平降低程度与尖波附近抑制作用一致,而1例不一致。本文结果提示,SSs可对theta节律产生瞬时、直接的抑制作用,该抑制作用可在无尖波暂态期持续,并可由theta节律断裂程度反映。该工作首次应用局部场电位证明了癫痫尖波对theta节律抑制作用可通过无尖波时脑电节律的断裂程度来评估,为利用脑电衡量癫痫尖波抑制作用提供了量化分析方法。
[Abstract]:Hippocampal CA3 and entorhinal cortex (entorhinal cortex,EC) network are one of the key circuits in the study of hippocampal cognitive function and temporal lobe epilepsy. The study of the inhibitory effect of sharp waves on the rhythm of hippocampal network theta (48 Hz) is helpful to reveal the mechanism of the effect of epilepsy on cognitive function. In the past, at the network level, the inhibitory effect was often evaluated quantitatively by brain slices. The purpose of this paper is to establish a method to evaluate the inhibitory effect of epileptic cusp on theta rhythm depending on the depth of brain field potential. In 4 patients with temporal lobe epilepsy who were in the condition of rapid eye movement (rapid eyes movement,REM) sleep before operation, the interictal sporadic sharp wave (sporadic spikes,SSs) EEG and the non-sharp wave transient EEG between the two adjacent SSs were selected from the cortical electrode records. The sharp waves appear only in EC, at CA3, or in CA3 and EC at the same time. Using Gabor wavelet and Hilbert transform to calculate the theta energy before and after the sharp wave and the transient phase without the sharp wave, and to calculate the breaking degree of the theta rhythm in the non-sharp wave transient phase. The results showed that: (1) the energy of theta could be instantly decreased by the sharp wave, and the decrease of CA3 and EC was the most severe, and the inhibitory effect was the strongest at the time of synchronous sharp wave of CA3 and EC; (2) the theta energy decreases and the theta rhythm disappears during the non-sharp wave transient period, which results in the rhythm breaking, indicating that the inhibition action is continuing, and the degree of the fracture is consistent with that near the sharp wave. (3) the decrease of theta energy level in 3 patients without sharp wave transient phase was consistent with the inhibitory effect near the sharp wave, but not in 1 case. The results suggest that SSs can produce transient and direct inhibitory effect on theta rhythm, which can be sustained during the non-sharp wave transient period, and can be reflected by the breaking degree of theta rhythm. For the first time, the local field potential has proved that the inhibitory effect of epileptic sharp waves on theta rhythm can be evaluated by the breaking degree of EEG rhythm without sharp waves, which provides a quantitative analysis method for the use of EEG to measure the inhibitory effect of epileptic sharp waves.
【作者单位】：河北工业大学电磁场与磁性材料省部共建国家重点实验室电气工程学院;
【分类号】：Q4

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