早期康复联合丁苯酞注射液治疗急性脑梗塞的疗效观察
发布时间：2018-11-27 14:53
【摘要】：[目的]比较早期康复联合丁苯酞注射液与单纯应用丁苯酞注射液等药物治疗急性脑梗塞患者肢体功能障碍的疗效,对两组患者治疗1周、2周的肢体运动功能、日常生活能力(ADL)进行评价,分析早期康复在丁苯酞注射液治疗条件下不同时间的疗效及其应用价值。[方法]选取符合纳入标准的急性脑梗塞患者70例,均为发病48h内就诊并应用丁苯酞注射液治疗,生命体征稳定,神经系统症状48h无进展。随机将患者分为康复组35例与对照组35例,康复组患者在入院治疗3d内给予早期规范化物理治疗。经实验过程筛选,实际最终进入统计分析为康复组29例和对照组30例。对比两组患者入选时、治疗1周、治疗2周的简化Fugl-Meyer运动功能评定法(Fugl-Meyer assessment,FMA)和 Barthel 指数(the Barthel index,BI)评分,分析康复组与对照组在肢体运动功能和日常生活能力的恢复情况。[结果]1.康复组与对照组在入组时FMA评分无统计学差异(P0.05)。在入组时、治疗1周、治疗2周的评定中,对照组的FMA评分第1周从25.32±5.76升至36.58±6.11,增加约11.26分,第二周从升至42.63±8.09,增加约6.05分,共增加约17.31分,表明对照组经丁苯酞注射液等药物治疗肢体运动功能得到一定恢复。康复组FMA评分在治疗1周从27.55±5.94升至41.07±6.47,增加约13.52分,与对照组无统计学差异(P0.05),但在治疗第2周从41.07±6.47升至50.48±6.13,增加约9.41分,共增加约22.93分,较对照组具有统计学差异(P0.05);对照组与康复组FMA升高均以第1周较显著。2康复组和对照组入组时BI评分的差异无统计学意义(P0.05)。在入组时、治疗1周、治疗2周的评定中,虽然对照组评分也逐渐增高,从19.52±6.10分增加到35.67±7.74分,增加约16.61分,但康复组从20.52±6.03分增加至40.42±7.48分,增约19.90分,增加幅度明显高于对照组,具有统计学差异(P0.05)。康复组与对照组在各次评定之间比较差异均有统计学意义(P0.05)。[结论]1.早期康复联合丁苯酞注射液治疗与单纯应用丁苯酞注射液药物治疗的急性脑梗塞患者2周疗效相比,早期康复治疗的患者肢体运动功能恢复较好,能更好的改善日常生活能力。2.丁苯酞注射液治疗的急性脑梗塞患者,肢体运动功能的恢复及ADL的改善,治疗第1周较治疗第2周明显。3.早期康复联合丁苯酞注射液与单纯应用丁苯酞注射液药物治疗急性脑梗塞患治疗者第1周肢体功能与ADL改善程度无统计学差异的原因有丁苯酞注射液药物治疗的影响和康复治疗时间较短。
[Abstract]:[objective] to compare the effects of early rehabilitation combined with butyphthalide injection and butyphthalide injection on limb dysfunction in patients with acute cerebral infarction. Ability of daily living (ADL) was evaluated and the effect of early rehabilitation on butyphthalide injection at different time and its application value were analyzed. [methods] A total of 70 patients with acute cerebral infarction who met the inclusion criteria were selected. All patients were treated with butyphthalide injection within 48 hours after onset of the disease. The vital signs were stable and the neurological symptoms had no progress for 48 hours. The patients were randomly divided into rehabilitation group (n = 35) and control group (n = 35). The results showed that 29 cases in rehabilitation group and 30 cases in control group were involved in the statistical analysis. The scores of simplified Fugl-Meyer motor function assessment (Fugl-Meyer assessment,FMA) and Barthel index (the Barthel index,BI) were compared between the two groups during the first week of treatment and 2 weeks of treatment. The recovery of motor function and ADL in rehabilitation group and control group were analyzed. [result] 1. There was no significant difference in FMA score between rehabilitation group and control group (P0.05). The FMA score of the control group increased from 25.32 卤5.76 to 36.58 卤6.11 in the first week, increased by 11.26 points, and increased from 42.63 卤8.09 to about 6.5 points in the second week. The total increase of 17.31 points indicated that the limb motor function of the control group was recovered after treatment with butyphthalide injection and other drugs. The FMA score of the rehabilitation group increased from 27.55 卤5.94 to 41.07 卤6.47 at 1 week, which increased by 13.52 points. There was no significant difference between the rehabilitation group and the control group (P0.05), but at the second week of treatment, the score rose from 41.07 卤6.47 to 50.48 卤6.13. Increase about 9.41 points, a total increase of 22.93 points, compared with the control group has statistical difference (P0.05); The increase of FMA in the control group and rehabilitation group was significantly higher than that in the first week. 2 there was no significant difference in BI score between the rehabilitation group and the control group when entering the group (P0.05). The scores of the control group increased gradually from 19.52 卤6.10 to 35.67 卤7.74, an increase of 16.61 points in the evaluation of the first week of treatment and 2 weeks of treatment on the first week of treatment and 2 weeks of treatment, and the scores of the control group increased gradually, from 19.52 卤6.10 to 35.67 卤7.74, respectively. But in the rehabilitation group, the score increased from 20.52 卤6.03 to 40.42 卤7.48, an increase of about 19.90, which was significantly higher than that of the control group (P0.05). There were significant differences between the rehabilitation group and the control group in each evaluation (P0.05). [conclusion] 1. Compared with the patients with acute cerebral infarction treated with butyphthalide injection alone, the early rehabilitation therapy combined with butyphthalide injection had better recovery of limb motor function than that of patients with acute cerebral infarction treated with butyphthalide injection alone for 2 weeks. Can better improve the ability of daily life. 2. The recovery of limb motor function and the improvement of ADL in patients with acute cerebral infarction treated with butyphthalide injection were significantly higher in the first week than in the second week. Early rehabilitation combined with butyphthalide injection and butyphthalide injection alone in the treatment of acute cerebral infarction patients had no significant difference in limb function and ADL improvement in the first week. The time of influence and rehabilitation was shorter.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3
本文编号：2361182
[Abstract]:[objective] to compare the effects of early rehabilitation combined with butyphthalide injection and butyphthalide injection on limb dysfunction in patients with acute cerebral infarction. Ability of daily living (ADL) was evaluated and the effect of early rehabilitation on butyphthalide injection at different time and its application value were analyzed. [methods] A total of 70 patients with acute cerebral infarction who met the inclusion criteria were selected. All patients were treated with butyphthalide injection within 48 hours after onset of the disease. The vital signs were stable and the neurological symptoms had no progress for 48 hours. The patients were randomly divided into rehabilitation group (n = 35) and control group (n = 35). The results showed that 29 cases in rehabilitation group and 30 cases in control group were involved in the statistical analysis. The scores of simplified Fugl-Meyer motor function assessment (Fugl-Meyer assessment,FMA) and Barthel index (the Barthel index,BI) were compared between the two groups during the first week of treatment and 2 weeks of treatment. The recovery of motor function and ADL in rehabilitation group and control group were analyzed. [result] 1. There was no significant difference in FMA score between rehabilitation group and control group (P0.05). The FMA score of the control group increased from 25.32 卤5.76 to 36.58 卤6.11 in the first week, increased by 11.26 points, and increased from 42.63 卤8.09 to about 6.5 points in the second week. The total increase of 17.31 points indicated that the limb motor function of the control group was recovered after treatment with butyphthalide injection and other drugs. The FMA score of the rehabilitation group increased from 27.55 卤5.94 to 41.07 卤6.47 at 1 week, which increased by 13.52 points. There was no significant difference between the rehabilitation group and the control group (P0.05), but at the second week of treatment, the score rose from 41.07 卤6.47 to 50.48 卤6.13. Increase about 9.41 points, a total increase of 22.93 points, compared with the control group has statistical difference (P0.05); The increase of FMA in the control group and rehabilitation group was significantly higher than that in the first week. 2 there was no significant difference in BI score between the rehabilitation group and the control group when entering the group (P0.05). The scores of the control group increased gradually from 19.52 卤6.10 to 35.67 卤7.74, an increase of 16.61 points in the evaluation of the first week of treatment and 2 weeks of treatment on the first week of treatment and 2 weeks of treatment, and the scores of the control group increased gradually, from 19.52 卤6.10 to 35.67 卤7.74, respectively. But in the rehabilitation group, the score increased from 20.52 卤6.03 to 40.42 卤7.48, an increase of about 19.90, which was significantly higher than that of the control group (P0.05). There were significant differences between the rehabilitation group and the control group in each evaluation (P0.05). [conclusion] 1. Compared with the patients with acute cerebral infarction treated with butyphthalide injection alone, the early rehabilitation therapy combined with butyphthalide injection had better recovery of limb motor function than that of patients with acute cerebral infarction treated with butyphthalide injection alone for 2 weeks. Can better improve the ability of daily life. 2. The recovery of limb motor function and the improvement of ADL in patients with acute cerebral infarction treated with butyphthalide injection were significantly higher in the first week than in the second week. Early rehabilitation combined with butyphthalide injection and butyphthalide injection alone in the treatment of acute cerebral infarction patients had no significant difference in limb function and ADL improvement in the first week. The time of influence and rehabilitation was shorter.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3
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