左乙拉西坦与拉莫三嗪治疗丙戊酸无效型成人难治性癫痫部分性发作的效果比较

发布时间：2018-12-06 09:48

【摘要】：目的比较左乙拉西坦、拉莫三嗪治疗丙戊酸无效型成人难治性癫痫部分性发作的临床效果。方法选取丙戊酸无效型成人难治性癫痫部分性发作患者120例,随机分为左乙拉西坦组55例与拉莫三嗪组65例。两组均维持原有丙戊酸治疗方案,左乙拉西坦组加用左乙拉西坦、拉莫三嗪组加用拉莫三嗪,均连续治疗6个月。比较两组治疗效果;治疗前后进行脑电图检查,计数20 min内清醒期脑电图痫样放电(IEA)次数,统计与治疗前比较IEA消失、减少≥50%、减少50%、无变化、增加的患者比例,计算α节律及δ、θ、α、β各频段功率;统计持续用药3、6个月用药保留率;记录两组用药期间不良反应发生率。结果拉莫三嗪组总有效率80.00%(52/65),左乙拉西坦组为69.09%(38/55),两组比较P0.05。持续用药6个月结束时,两组IEA消失、减少≥50%、减少50%的患者比例比较P均0.05;拉莫三嗪组IEA无变化及增加的患者比例均大于左乙拉西坦组(P均0.05)。两组治疗前后α节律及δ、θ、α、β频段功率均无明显变化,组间及组内比较差异均无统计学意义(P均0.05)。左乙拉西坦组、拉莫三嗪组用药3个月时用药保留率均为100%;用药6个月时分别为60.00%(33/55)、76.92%(50/65),组间比较P0.05。治疗期间,左乙拉西坦组不良反应以嗜睡多见,拉莫三嗪组以皮疹多见,但两组各不良反应发生率比较差异均无统计学意义(P均0.05)。结论左乙拉西坦与拉莫三嗪对丙戊酸无效型难治性癫痫部分性发作的治疗效果相当。
[Abstract]:Objective to compare the clinical effects of levoethoxetam and lamotrigine in the treatment of refractory partial seizures in adults with valproic acid ineffectiveness. Methods one hundred and twenty patients with partial seizure of refractory epilepsy with valproic acid ineffectual type were randomly divided into levoethylacetam group (55 cases) and lamotriazine group (65 cases). The original valproic acid regimen was maintained in both groups. The levoethoxetam group and lamotrigine group were treated with levoethylacetam and lamotrigine for 6 months. The therapeutic effects were compared between the two groups. EEG examination was performed before and after treatment, and the number of epileptiform discharges of epileptiform discharge in awake period within 20 min was counted. Compared with before and after treatment, IEA disappeared, decreased 鈮，

本文编号：2365847