前循环脑梗死患者血清PLGF水平与颈动脉粥样斑块超声特征的相关性研究
发布时间：2018-12-14 10:55
【摘要】：目的通过对颈内动脉系脑梗死患者进行颈动脉彩超检查,结合检测胎盘生长因子(PLGF)水平,探寻颈动脉易损斑块的敏感生物学标志物。方法根据颈动脉超声检查情况分为无斑块组、稳定斑块组、不稳定斑块组。对照组为年龄、性别与脑梗死组相匹配的同期住院的非脑血管病患者58例。所有研究对象均采用固相夹心法酶联免疫吸附实验(ELISA)测定血清PLGF,并进行颈动脉超声检查和卒中危险因素的测定,资料中数据均应用SPSS17.0软件进行分析。结果 (1)脑梗死组PLGF水平高于对照组,CAS斑块总检出率及不稳定斑块检出率高于对照组,差异有统计学意义(P0.05);(2)不稳定斑块组PLGF水平高于稳定斑块组和无斑块组(P0.05);结论 (1)急性脑梗死患者PLGF水平增高,提示PLGF参与了脑梗死的发生发展过程;(2)急性脑梗死患者不稳定斑块组PLGF水平高于稳定斑块组和无斑块组,提示PLGF水平越高,CAS斑块的稳定性越差,PLGF可作为颈动脉易损斑块的敏感生物学标志物来评估颈动脉病变的严重程度。
[Abstract]:Objective to explore the sensitive biomarkers of carotid artery vulnerable plaques by detecting the level of placental growth factor (PLGF) by color Doppler ultrasonography in patients with cerebral infarction of internal carotid artery. Methods according to carotid ultrasound examination, the patients were divided into three groups: no plaque group, stable plaque group and unstable plaque group. The control group consisted of 58 non-cerebrovascular disease patients who were matched by age, sex and cerebral infarction group. Serum PLGF, was determined by solid phase sandwich enzyme-linked immunosorbent assay (ELISA), carotid ultrasound and risk factors of stroke were determined. The data were analyzed by SPSS17.0 software. Results (1) the level of PLGF in the cerebral infarction group was higher than that in the control group, and the total detection rate of CAS plaque and the detection rate of unstable plaque were higher than those in the control group (P0.05). (2) the level of PLGF in unstable plaque group was higher than that in stable plaque group and no plaque group (P0.05). Conclusion (1) the level of PLGF in patients with acute cerebral infarction is increased, indicating that PLGF is involved in the occurrence and development of cerebral infarction. (2) the level of PLGF in unstable plaque group was higher than that in stable plaque group and no plaque group, suggesting that the higher the level of PLGF, the worse the stability of CAS plaque. PLGF can be used as a sensitive biomarker to evaluate the severity of carotid artery lesions.
【作者单位】： 开封市中心医院神经内科;
【分类号】：R743.33
[Abstract]:Objective to explore the sensitive biomarkers of carotid artery vulnerable plaques by detecting the level of placental growth factor (PLGF) by color Doppler ultrasonography in patients with cerebral infarction of internal carotid artery. Methods according to carotid ultrasound examination, the patients were divided into three groups: no plaque group, stable plaque group and unstable plaque group. The control group consisted of 58 non-cerebrovascular disease patients who were matched by age, sex and cerebral infarction group. Serum PLGF, was determined by solid phase sandwich enzyme-linked immunosorbent assay (ELISA), carotid ultrasound and risk factors of stroke were determined. The data were analyzed by SPSS17.0 software. Results (1) the level of PLGF in the cerebral infarction group was higher than that in the control group, and the total detection rate of CAS plaque and the detection rate of unstable plaque were higher than those in the control group (P0.05). (2) the level of PLGF in unstable plaque group was higher than that in stable plaque group and no plaque group (P0.05). Conclusion (1) the level of PLGF in patients with acute cerebral infarction is increased, indicating that PLGF is involved in the occurrence and development of cerebral infarction. (2) the level of PLGF in unstable plaque group was higher than that in stable plaque group and no plaque group, suggesting that the higher the level of PLGF, the worse the stability of CAS plaque. PLGF can be used as a sensitive biomarker to evaluate the severity of carotid artery lesions.
【作者单位】： 开封市中心医院神经内科;
【分类号】：R743.33
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【共引文献】
相关期刊论文 前6条
1 刘美香;马丽丽;蔡姝萍;;前循环脑梗死患者血清PLGF水平与颈动脉粥样斑块超声特征的相关性研究[J];中风与神经疾病杂志;2017年03期
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