颅内动脉瘤患者瘤壁雌激素和雄激素受体的表达及其作用

发布时间：2018-12-17 00:48

【摘要】：目的探讨颅内动脉瘤壁雌激素和雄激素受体表达水平的意义。方法前瞻性纳入2007年11月至2016年6月在四川大学华西医院接受开颅手术夹闭颅内动脉瘤的患者32例,获得颅内动脉瘤壁19个,颞浅动脉分支26个,共45个合格标本。采用免疫组化法检测颞浅动脉分支和颅内动脉瘤壁平滑肌层及内皮细胞的雌激素受体-α、β及雄激素受体表达水平。以Image Pro Plus6.0软件分析检测阳性细胞表达水平积分光密度值。统计学分析采用χ2检验,成组Mann-Whitney秩和检验。结果动脉瘤壁的雌激素受体-α、β表达中位数(M)与四分位距(P25,P75)分别为3 049(2 112,5 554)和4 364(2 314,5 667),低于颞浅动脉分支的6 544(3 507,10 103)和6 972(5 694,10 024)。动脉瘤壁雄激素受体表达水平3 299(1 375,4 895),高于颞浅动脉分支的1 130(794,1 922),两组比较差异均有统计学意义(均P0.05)。结论脑血管壁雌激素受体-α、β表达水平的降低,雄激素受体表达水平的升高,可能促进了颅内动脉瘤的进展,但具体机制尚需进一步研究。
[Abstract]:Objective to investigate the expression of estrogen and androgen receptors in intracranial aneurysms. Methods Thirty-two patients with intracranial aneurysms underwent craniotomy from November 2007 to June 2016 in Huaxi Hospital of Sichuan University were included. Nineteen intracranial aneurysms and 26 branches of superficial temporal artery were obtained and 45 qualified specimens were obtained. The expression of estrogen receptor- 伪, 尾 and androgen receptor in smooth muscle layer and endothelial cells of the branches of superficial temporal artery and intracranial aneurysm were detected by immunohistochemical method. The integrated optical density of positive cells was measured by Image Pro Plus6.0 software. 蠂 2 test and Mann-Whitney rank sum test were used in statistical analysis. Results the median (M) and quartile distance of estrogen receptor- 伪 and 尾 expression in aneurysms were 3 049 (2 112 554) and 4 364 (2 314 5 667), respectively. It was lower than the branches of superficial temporal artery (6 544 (3 507) 10 103) and 6 972 (5 694) (10 024). The expression level of androgen receptor in aneurysm wall was 3 299 (1 375 ~ 4 895), which was higher than that in superficial temporal artery (1 130) (79 4 ~ 1 922). The difference between the two groups was statistically significant (P0.05). Conclusion the decrease of estrogen receptor-伪, 尾 expression level and the increase of androgen receptor expression may promote the development of intracranial aneurysms, but the specific mechanism needs to be further studied.
【作者单位】：四川大学华西医院神经外科;德阳市人民医院神经外科;
【基金】：四川省科技支撑计划项目(2016SZ0015)
【分类号】：R743

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