真实世界的参芎葡萄糖注射液临床联合用药特征分析

发布时间：2019-01-09 15:10

【摘要】：为了分析真实世界参芎葡萄糖注射液的临床用药特征,提取全国19家三甲医院信息系统(HIS)数据库中使用参芎葡萄糖注射液患者的基本信息、中西医诊断信息、医嘱信息、实验室检查信息,采用Apriori算法建立模型,使用Clementine12.0进行关联分析,分析真实世界中参芎葡萄糖注射液临床用药及联合用药特征。符合纳入标准的8 316例患者的联合用药中,共包含523种西药和148种中药。联合用药频次最高的单个西药是阿司匹林1 908例(22.94%),单个中药是疏血通注射液771例(9.27%);2种中药是仙灵骨葆胶囊+鹿瓜多肽(规则支持度是2.55%),2种西药是阿托伐他汀+阿司匹林(关联规则度为10.15%);常与抗生素类、活血化瘀剂、肾上腺皮质激素类药物联合应用。参芎葡萄糖注射液临床上常与抗血小板药和活血化瘀药联合应用,有助于增强抗血小板聚集和活血化瘀作用;常与抗生素联合应用,治疗肺源性心脏病,注意联合应用时的配伍禁忌,保证临床用药安全性的前提下二者联合用药达到药效增强的作用。
[Abstract]:In order to analyze the clinical characteristics of Shenxiong glucose injection in the real world, the basic information, diagnostic information and doctor's order information of Shenxiong glucose injection were extracted from the (HIS) database of 19 third-class hospitals in China. The information of laboratory was examined and the model was established by Apriori algorithm. The association analysis was carried out with Clementine12.0 to analyze the clinical and combined drug use characteristics of Shenxiong glucose injection in the real world. There were 523 kinds of western medicine and 148 kinds of traditional Chinese medicine in 8 316 patients. The highest frequency of combined medicine was aspirin in 1 908 cases (22.94%) and Shuxuetong injection in 771 cases (9.27%). The two kinds of Chinese medicine are Xianling Gubao capsule deer melon polypeptide (rule support is 2.55%), two western medicine is Atto vastatin aspirin (association rule is 10.15%); It is often combined with antibiotics, blood-activating agents and adrenal corticosteroids. Shenxiong glucose injection is often used in combination with antiplatelet drugs and drugs to promote blood circulation and remove blood stasis, which is helpful to enhance the effect of anti-platelet aggregation and promoting blood circulation and removing blood stasis. Often combined with antibiotics, the treatment of pulmonary heart disease, pay attention to the combined use of incompatibility taboos, to ensure the safety of clinical use of the premise that the combined use of the two drugs to achieve the effect of enhancing the effect.
【作者单位】：中国中医科学院中医临床基础医学研究所;中国人民大学统计学院;中国人民解放军海军总医院;
【基金】：国家“重大新药创制”科技重大专项(2015ZX09501004-001-002) 国家中医药管理局中医药行业科研专项(201507003) 北京市中医药科技发展专项(JJ2014-53)
【分类号】：R742

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