急性脑梗死患者血浆内皮损伤标志物的变化及其临床意义

发布时间：2019-02-13 01:56

【摘要】：目的探讨血浆内皮损伤标志物与急性脑梗死(ACI)的关系。方法对630例ACI患者血浆超氧化物歧化酶(SOD)、甘胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)、一氧化氮合酶(NOS)、脂质过氧化物酶(LPO)、血栓调节蛋白(STM)、胱抑素C(Cys-C)进行检测和分析,选择健康人群210例作为对照组;采用TCD颈脑血管超声检查组合进行检查,同时参照头部CT或MRI检查,按颈动脉狭窄程度、斑块大小和梗死灶大小将630例患者分为重度组(病灶体积10 cm3),中度组(病灶体积4~10 cm3),轻度组(病灶体积4 cm3),三组各210例。结果与对照组比较,ACI组SOD、NOS、STM、Cys-C水平明显偏高(P0.01);血浆NO、NOS、LPO、STM、Cys-C水平与颈动脉狭窄程度、斑块大小和脑梗死灶大小有关,而血浆SOD、GSH-Px随着病情的加重而下降(P0.05)。结论检测内皮损伤标志物水平对于ACI早期诊断、病情评估和预后判断有重要的临床意义。
[Abstract]:Objective to investigate the relationship between plasma endothelial injury markers and acute cerebral infarction (ACI). Methods Plasma superoxide dismutase (SOD), (SOD), glutathione peroxidase (GSH-Px), nitric oxide (NO), nitric oxide synthase (NOS), lipid peroxidase (LPO), thrombomodulin (STM), (STM),) were studied in 630 patients with ACI. Cystatin C (Cys-C) was detected and analyzed. 210 healthy subjects were selected as control group. The patients were divided into severe group (focus volume 10 cm3) according to the degree of carotid artery stenosis, plaque size and infarct size according to the CT or MRI examination of the head, using the combination of TCD carotid and cerebrovascular ultrasound examination, and according to the degree of carotid artery stenosis, the size of plaque and the size of infarct. There were 210 cases in the middle group (4 ~ 10 cm3) and in the light group (4 cm3). Results compared with the control group, the level of SOD,NOS,STM,Cys-C in ACI group was significantly higher than that in control group (P0.01). Plasma NO,NOS,LPO,STM,Cys-C levels were correlated with carotid stenosis, plaque size and cerebral infarction size, while plasma SOD,GSH-Px levels decreased with the severity of the disease (P0.05). Conclusion Detection of endothelial injury markers has important clinical significance in early diagnosis, evaluation and prognosis of ACI.
【作者单位】：江苏大学附属人民医院核医学科;江苏大学附属第四人民医院神经内科;江苏大学医学院;
【基金】：江苏省高校自然科学研究基金(No.10KJB310003) 江苏大学医学临床科技发展基金项目资助(No.JLY20140016)
【分类号】：R743.33

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