脑梗死患者血清骨保护素水平与颈动脉粥样硬化斑块的关系

发布时间：2019-02-14 22:56

【摘要】：目的：本实验通过对脑梗死（cerebral infarction，CI）患者不同类型的颈动脉斑块组与健康对照组的血清骨保护素（osteoprotegerin，OPG）水平变化进行比较，探讨OPG水平与脑梗死及粥样硬化斑块稳定性的关系。方法：收集2012年11月至2013年8月医院神经内科住院的脑梗死患者96例，均行颈动脉多普勒彩超检查评估有无斑块，，分为有斑块组64例和无斑块组32例，根据斑块性质分为稳定斑块组30例和不稳定斑块组34例，同时收集31例健康体检者。采用酶联免疫测定法（ELISA）检测血清OPG水平，采用SPSS17.0统计软件进行统计分析，观察脑梗死组与健康对照组之间OPG水平变化情况，同时分析脑梗死患者颈动脉斑块稳定程度不同时的OPG浓度变化趋势，以及血清OPG与患者一般指标之间的相关性。结果：四组血清OPG水平比较差异均有统计学意义，健康对照组血清OPG水平均低于其余三组，差异有统计学意义（P＜0.05）；脑梗死颈动脉无斑块组血清OPG水平低于脑梗死合并颈动脉稳定斑块组，差异有统计学意义（P＜0.05），脑梗死合并颈动脉稳定斑块组血清OPG水平低于脑梗死合并颈动脉不稳定斑块组，差异有统计学意义（P＜0.05）。相关分析示：脑梗死患者血清OPG与CRP、Hcy呈正相关（P＜0.05）。结论：血清OPG水平与脑梗死有关。血清OPG与脑梗死颈动脉粥样硬化斑块的不稳定性相关。
[Abstract]:Objective: to compare the changes of serum osteoprotegerin (osteoprotegerin,OPG) levels in patients with cerebral infarction (cerebral infarction,CI) in different types of carotid plaque group and healthy control group. To investigate the relationship between OPG level and the stability of cerebral infarction and atherosclerotic plaque. Methods: from November 2012 to August 2013, 96 patients with cerebral infarction in Department of Neurology, Hospital were examined by carotid Doppler color Doppler ultrasonography to evaluate whether there were plaques, which were divided into two groups: 64 cases with plaque and 32 cases without plaque. According to the nature of plaque, 30 cases of stable plaque group and 34 cases of unstable plaque group were divided into stable plaque group and unstable plaque group, and 31 healthy persons were collected at the same time. The levels of serum OPG were detected by (ELISA) and SPSS17.0 software. The changes of OPG levels between cerebral infarction group and healthy control group were observed. At the same time, the change trend of OPG concentration and the correlation between serum OPG and general indexes of patients with cerebral infarction were analyzed. Results: there were significant differences in serum OPG levels among the four groups, and the serum OPG levels in the healthy control group were lower than those in the other three groups (P < 0. 05). The serum OPG level in the carotid artery without plaque group was significantly lower than that in the cerebral infarction with carotid artery stable plaque group (P < 0. 05). The level of serum OPG in the cerebral infarction with carotid artery stable plaque group was lower than that in the cerebral infarction complicated with carotid artery unstable plaque group (P < 0. 05). Correlation analysis showed that there was a positive correlation between serum OPG and CRP,Hcy in patients with cerebral infarction (P < 0. 05). Conclusion: serum OPG level is related to cerebral infarction. Serum OPG was associated with the instability of carotid atherosclerotic plaque in cerebral infarction.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3

【相似文献】