帕金森病患者非运动症状调查及其生活质量影响因素分析

发布时间：2019-02-21 12:07

【摘要】：目的：研究帕金森病患者的非运动症状、生活质量及其相关影响因素分析。方法：选取2011年9月至2013年8月在南昌大学第二附属医院神经内科门诊就诊及住院部住院的原发性帕金森病（Parkinson disease，PD）患者116例。采用非运动症状筛查量表(Non-Motor Symptoms Questionnaire，，NMSQuest)、汉密尔顿抑郁量表（Hamilton Depression Scale，HAMD）、39项帕金森病生存质量调查表（the39-item Parkinson’s Disease Questionnaire，PDQ-39）、改良Hoehn-Yahr分级量表（Hoehn-Yahr stages，H-Y）、帕金森病睡眠量表(Parkinson’s disease sleep scale，PDSS）评估PD患者的非运动症状、抑郁程度、生活质量以及睡眠质量。结果：116例PD患者中有113例存在NMS，平均个数为（8.12±5.4）。便秘发生率最高，占74.1%；其次为记忆力下降和对周围发生的事情失去兴趣，分别占57．7%和49.1%。NMS发生数与病程（r=0.327）、H-Y分级（r=0.346）、HAMD评分（r=0.356）及PDSS评分（r=-0.300）相关。多元线性回归分析显示病程、H-Y分级、抑郁是NMS发生数的主要影响因素。PD患者生存质量受损最明显的是日常活动，其次为认知力，运动能力；交往和社会支持维度受损最轻。相关分析得出NMS个数（r=0.392）、H-Y分级（r=0.590）、HAMD评分（r=0.445）、PDSS评分（r=-0.594）与生存质量密切相关。多元线性回归分析得出睡眠质量、H-Y分级和抑郁是影响PD患者生存质量的主要因素。结论：1、非运动症状在PD患者中发生率高，便秘、记忆力下降、缺乏兴趣是最常见的NMS；2、病程、病情程度、抑郁是NMS发生数的主要影响因素；3、PD患者抑郁、睡眠障碍发生率高，最常见抑郁症状是兴趣缺乏，夜尿是最常见睡眠问题；4、PD患者生存质量受损最明显的是日常活动、认知力、运动能力；5、睡眠质量、病情程度和抑郁是影响PD患者生存质量的主要因素。
[Abstract]:Objective: to study the non-motor symptoms, quality of life and related factors of Parkinson's disease. Methods: from September 2011 to August 2013, 116 patients with primary Parkinson's disease (Parkinson disease,PD) were enrolled in the Department of Neurology, second affiliated Hospital of Nanchang University. Nonmotor symptom screening scale (Non-Motor Symptoms Questionnaire,NMSQuest), Hamilton Depression scale (Hamilton Depression Scale,HAMD), and 39 items of Parkinson's Disease quality of Life (the39-item Parkinson's Disease Questionnaire,PDQ-39) were used. Modified Hoehn-Yahr rating scale (Hoehn-Yahr stages,H-Y) and Parkinson's Disease Sleep scale (Parkinson's disease sleep scale,PDSS) were used to evaluate non-motor symptoms, degree of depression, quality of life and sleep quality of PD patients. Results: the average number of NMS, in 113 patients with PD was (8.12 卤5.4). The incidence of constipation was the highest (74.1%). The second was memory loss and loss of interest in the surrounding events, accounting for 57.7%, and the incidence of 49.1%.NMS and course of disease (rn 0.327), H-Y grade (rr 0.346), HAMD score (r = 0.356) and PDSS score (r = -0.300) were correlated. Multiple linear regression analysis showed that the course of disease, H-Y grade and depression were the main factors influencing the occurrence of NMS. The most significant impairment of quality of life in PD patients was daily activities, followed by cognitive ability and motor ability. The dimension of communication and social support is least damaged. Correlation analysis showed that the number of NMS (r = 0.392) and H-Y grade (r = 0.590), HAMD) (r = 0.445), PDSS) were closely related to the quality of life. Multiple linear regression analysis showed that sleep quality, H-Y grade and depression were the main factors affecting the quality of life in patients with PD. Conclusion: 1 the incidence of non-motor symptoms in PD patients is high, constipation, memory decline, lack of interest is the most common course of NMS;2, the degree of illness, depression is the main factors affecting the number of NMS; 3The incidence of depression and sleep disorder in PD patients was high, the most common depressive symptom was lack of interest, the nocturnal urine was the most common sleep problem, and the most obvious impairment of quality of life in PD patients was daily activity, cognitive ability and motor ability. 5. Sleep quality, severity of illness and depression were the main factors affecting the quality of life in patients with PD.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.5

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