黛力新对脑卒中后焦虑的疗效的Meta分析

发布时间：2019-03-05 18:13

【摘要】：背景:脑卒中后焦虑障碍(PSAD)是脑血管病后常见的并发症之一,因为其可严重影响患者及其照顾者的生活质量,甚至可增加脑血管病患者的病死率,因此对脑卒中后焦虑的早期诊断及治疗是提高患者及照顾者生存质量和降低病死率的有效途径。但目前关于药物治疗脑卒中后焦虑的专门临床研究较少。黛力新是治疗焦虑障碍非常有效的一种化合物复方制剂,然而,目前仅有很少一部分的试验研究了黛力新对脑卒中后焦虑的治疗效果。目的:本文旨在通过Meta分析评价黛力新治疗脑卒中后焦虑的疗效,为脑卒中后焦虑的治疗提供具有循证医学的最佳治疗方案。方法:计算机检索数据库(Cochrance Library、PubMed、WANFANG、CNKI、WEIPU等),查阅自1989年-2017年公开发表的有关黛力新治疗脑卒中后焦虑的相关文献。并根据纳入和排除的标准对文献进行筛选,并对筛选出的文章进行方法及质量评价,使用RevMan5.1软件对纳入的文章进行数据分析。结果:经过筛选,最终纳入6篇随机对照试验(RCT)文献,总共有600名患者。根据Meta分析数据显示,最终可得出黛力新治疗脑卒中后焦虑的治疗是有效的结论(OR为7.10 95%CI值是4.36-11.55,P0.05,I2=0)。结论:本文通过对现有RCT试验进行的Meta分析,得出黛力新对脑卒中后焦虑有明确的治疗效果。但是结果可能因为低质量的RCT而出现偏差,同时所纳入的文献的样本量均较小,故需要进行更多的高质量、大样本量的RCT来验证。
[Abstract]:Background: post-stroke anxiety disorder (PSAD) is one of the common complications after cerebrovascular disease, because it can seriously affect the quality of life of patients and their caregivers, and even increase the fatality rate of cerebrovascular disease patients. Therefore, the early diagnosis and treatment of post-stroke anxiety is an effective way to improve the quality of life and reduce the mortality of patients and caregivers. However, there are few clinical studies on drug treatment of post-stroke anxiety. Delixine is an effective compound for anxiety disorder. However, only a small number of trials have studied the therapeutic effect of Delixin on post-stroke anxiety. Aim: to evaluate the efficacy of Delixin in the treatment of post-stroke anxiety by Meta analysis, and to provide evidence-based medicine for the treatment of post-stroke anxiety. Methods: a computer-based search database (Cochrance Library,PubMed,WANFANG,CNKI,WEIPU et al.) was used to review the published literatures on the treatment of post-stroke anxiety with Delixin from 1989 to 2017. According to the criteria of inclusion and exclusion, the literature was screened, the methods and quality of the selected articles were evaluated, and the data of the articles were analyzed by using RevMan5.1 software. Results: six randomized controlled trials (RCT) were selected and included in 6 randomized controlled trials (RCTs) with a total of 600 patients. According to the data of Meta analysis, it was concluded that Delixin was effective in the treatment of post-stroke anxiety (OR = 7.10 95%CI = 4.36, 11.55, P 0.05, I _ 2 ~ 0). Conclusion: according to the Meta analysis of the existing RCT test, it is concluded that Delixin has a definite therapeutic effect on post-stroke anxiety. However, the results may be biased because of the low quality RCT, and the sample size of the literature is small. Therefore, more high quality, large sample size RCT should be carried out to verify the results.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3;R749.72

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