认知障碍简明评价表对帕金森病患者轻度认知功能障碍的诊断价值

发布时间：2019-03-06 19:55

【摘要】：目的探讨认知障碍简明评价表(Cog-12量表)对帕金森病(PD)患者轻度认知功能障碍的诊断价值。方法将85例PD患者按认知障碍诊断标准分为认知功能正常组(45例)、轻度认知功能障碍组(PD-MCI)组(40例)。采用Cog-12量表、蒙特利尔认知评估量表(MoCA)及MMSE量表对患者进行测评,分析3个量表对PD患者轻度认知障碍的筛查能力。结果与认知功能正常组比较,PD-MCI组Cog-12量表评分显著升高,MoCA、MMSE量表评分显著降低(均P0.001)。Cog-12对PD患者MCI的鉴别能力明显优于MoCA、MMSE(AUC_(Cog-12)=0.958,敏感度为85.7%,特异度为75%;AUC_(MMSE)=0.798,敏感度为52.4%,特异度为26.5%;AUC_(MoCA)=0.907,敏感度为71.4%,特异度为21.5%)。当Cog-12界值为7.5分时,其敏感性为85.7%。结论 Cog-12量表可有效检测PD患者的认知功能损伤,可应用于临床PD患者认知功能的筛查。
[Abstract]:Objective to investigate the diagnostic value of Cog- 12 scale for mild cognitive impairment in patients with Parkinson's disease (PD). Methods 85 patients with PD were divided into normal cognitive function group (45 cases) and mild cognitive impairment (PD-MCI) group (40 cases) according to the diagnostic criteria of cognitive impairment. Cog- 12 scale, Montreal Cognitive Assessment scale (MoCA) and MMSE scale were used to evaluate the screening ability of the three scales for mild cognitive impairment in PD patients. Results compared with the normal cognitive function group, the scores of Cog- 12 and MoCA,MMSE in PD-MCI group were significantly higher than those in normal cognitive function group (all P0.001). The ability of Cog-12 to differentiate MCI in PD patients was significantly better than that in MoCA, group (all P0.001). MMSE (AUC_ (Cog-12) = 0.958), sensitivity was 85.7%, specificity was 75%; AUC_ (MMSE) = 0.798, sensitivity 52.4%, specificity 26.5% AUC _ (MoCA) = 0.907, sensitivity 71.4%, specificity 21.5%). When the Cog-12 threshold is 7.5, the sensitivity is 85.7%. Conclusion Cog- 12 scale can effectively detect cognitive impairment in patients with PD and can be used to screen cognitive function in clinical PD patients.
【作者单位】：江苏省复员退伍军人精神病医院江苏省扬州五台山医院神经内科;扬州大学医学院附属医院江苏省苏北人民医院;
【分类号】：R742.5

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