发育迟缓儿童胼胝体的MRI特征

发布时间：2019-03-21 14:35

【摘要】：目的探讨磁共振测量胼胝体径线对儿童发育迟缓的评估价值。方法收集120例1~5岁发育迟缓儿童与120例年龄匹配的正常发育儿童的头颅MRI资料,按照生长规律分为6个年龄组,在T_1WI正中矢状面测量胼胝体膝部、体部、压部厚度及胼胝体长度,比较各年龄组发育迟缓儿童与正常儿童胼胝体参数的差异,并通过受试者工作特征(ROC)曲线分析各参数的诊断临界值。结果第1~4年龄组(1~3岁)发育迟缓儿童胼胝体膝部及体部较正常发育儿童变薄(P0.05),胼胝体长度及胼胝体压部厚度在两组之间无明显差异;第5、6年龄组(3~5岁)胼胝体各项参数在病例组与对照组间无明显差异。通过ROC曲线分析第1~4年龄组胼胝体膝部厚度临界值分别为8.1mm、7.5mm、8.9mm、9.2mm,敏感度分别为85.0%、60.0%、75.0%、60.0%,特异度分别为55.0%、95.0%、75.0%、85.0%;胼胝体体部厚度临界值为4.3mm、4.3mm、4.5mm、4.7mm,敏感度分别为65.0%、75.0%、75.0%、50%,特异度分别为80.0%、65.0%、95.0%、90.0%。结论胼胝体膝部及体部的厚度可反映1~3岁发育迟缓儿童脑白质体积变化,胼胝体径线测量有助于该年龄段儿童的发育评估。
[Abstract]:Objective to evaluate the value of magnetic resonance imaging (MRI) in measuring the diameter of corpus callosum in children with stunted growth. Methods the cranial MRI data of 120 children with 1-5-year-old stunting and 120 age-matched normal children were collected and divided into 6 age groups according to the growth pattern. The corpus callosum knee and body were measured on the median sagittal plane of T_1WI. The thickness of the callosum and the length of corpus callosum were compared between the stunted children and the normal children. The diagnostic critical values of the parameters were analyzed by the (ROC) curve of the subjects' operating characteristics. Results the length of corpus callosum and the thickness of corpus callosum pressure were not significantly different between the first and fourth age groups (1 ~ 4 years old) compared with the normal children (P0.05), and the length of corpus callosum and the thickness of corpus callosum pressure were not significantly different between the two groups. There was no significant difference in the parameters of corpus callosum in the 5th and 6th age groups (3 to 5 years old) between the patient group and the control group. According to ROC curve analysis, the critical thickness of the corpus callosum knee was 8.1 mm, 7.5 mm, 8.9 mm, 9.2 mm, the sensitivity was 85.0%, 60.0%, 75.0%, 60.0%, 60.0%, respectively. The specificity was 55. 0%, 95. 0%, 75. 0%, 85. 0%, respectively. The critical values of corpus callosum thickness were 4.3 mm, 4.3 mm, 4.5 mm, 4.7 mm, respectively. The sensitivity was 65.0%, 75.0%, 75.0% and 50%, respectively. The specificity was 80.0%, 65.0%, 95.0% and 90.0%, respectively. Conclusion the thickness of the geniculus and body of corpus callosum can reflect the changes of white matter volume in 3-year-old children with stunted growth. The measurement of corpus callosum diameter is helpful to evaluate the development of children in this age group.
【作者单位】：南通大学附属南通市妇幼保健院医学影像科;
【分类号】：R748;R445.2

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