丙戊酸钠合用利培酮治疗癫痫发作间期精神分裂症样精神病的研究

发布时间：2019-04-03 19:36

【摘要】：目的:探讨丙戊酸钠合用利培酮治疗癫痫发作间期精神分裂症样精神病的疗效、安全性及对认知功能的影响。方法:本研究是为期8周的双盲随机对照临床试验,将122例符合CCMD-3中癫痫所致精神障碍诊断标准,并筛选为癫痫发作间期精神分裂症样精神病的患者随机分为两组,研究组使用丙戊酸钠联合利培酮,对照组使用丙戊酸钠联合安慰剂。研究组60例,完成52例,对照组62例,完成53例。分别于基线、治疗第2周末、4周末、8周末进行评定。主要的疗效指标为治疗第8周末阳性和阴性症状量表(PANSS)评分较基线减分率。认知功能评估采用简易精神状态量表(MMSE)。安全性指标采用治疗时出现的症状量表(TESS)评定及记录癫痫发作情况。结果:治疗结束时,研究组在有效率、显效率方面,均优于对照组,有非常显著的统计学差异(P0.01)。两组治疗前后MMSE评分变化及组间MMSE评分比较差异均无统计学意义(P0.05)。治疗后,组间TESS评分比较差异无显著性(P0.05),治疗期间无患者出现癫痫发作。结论:利培酮对癫痫发作间期精神分裂症样精神病的疗效显著,副反应轻,诱发抽搐风险小。
[Abstract]:Aim: to investigate the efficacy, safety and cognitive function of sodium valproate combined with risperidone in the treatment of interictal schizophrenia-like psychosis. Methods: this study was an 8-week double-blind randomized controlled clinical trial in which 122 patients with psychotic disorder due to epilepsy in CCMD-3 were randomly divided into two groups, who were selected as interictal schizophrenia-like psychosis, and were randomly divided into two groups. Sodium valproate combined with risperidone was used in the study group and sodium valproate plus placebo in the control group. There were 60 cases in the study group, 52 cases completed, 62 cases in the control group, 53 cases completed. They were evaluated at baseline, 2nd weekend, 4th weekend, 8th weekend. The main therapeutic index was the reduction rate of the (PANSS) score of the positive and negative symptoms scale compared with the baseline at the end of the 8th week of treatment. A simplified Mental State scale (MMSE).) was used to assess cognitive function. The safety index was assessed by symptom scale (TESS) during treatment and the seizure was recorded. Results: at the end of the treatment, the study group was superior to the control group in effective rate and significant efficiency, and there was a very significant difference (P0.01). There was no significant difference in MMSE score and MMSE score between the two groups before and after treatment (P0.05). After treatment, there was no significant difference in TESS score between groups (P0.05). Conclusion: risperidone is effective in the treatment of schizophrenia-like psychosis in interictal epilepsy with mild side effects and low risk of convulsions.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R742.1

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