替罗非班在支架辅助颅内动脉瘤栓塞中的安全性及有效性
发布时间：2019-04-18 12:47
【摘要】：目的探讨替罗非班用于支架辅助动脉瘤栓塞的安全性及有效性。方法分析31例采用支架辅助治疗动脉瘤患者的临床资料,分为阿司匹林联合氯吡格雷组(双抗组,n=18)、替罗非班组(n=13)。替罗非班组在支架半释放或完全释放后开始使用替罗非班。术后随访评估患者有无新发梗死、支架通畅情况及动脉瘤栓塞效果。术前1天、术后3天分别检测患者血小板计数及活化部分凝血活酶时间(APTT)。使用格拉斯哥预后评分(GOS)评价患者临床预后,记录术中、术后并发症。结果 31例患者共发现动脉瘤34个,处理动脉瘤32个。术后随访动脉瘤栓塞后复发7例,泌尿系统出血1例,未出现腹膜后、胃肠道出血,未出现术后新发脑梗死及血栓栓塞事件。27例GOS评分≥4。两组术前、术后血小板计数及APTT差异均无统计学意义(P均0.05)。结论替罗非班应用于支架辅助动脉瘤栓塞安全、有效,紧急情况下可以作为双抗的替代方案。
[Abstract]:Objective to evaluate the safety and efficacy of stent-assisted embolization of aneurysm with tirofiban. Methods the clinical data of 31 patients with aneurysm treated with stent-assisted therapy were analyzed and divided into aspirin combined clopidogrel group (double antibody group, n = 18) and tirofiban group (n = 13). The tirofiban group began to use tirofiban after half-release or complete release of the stent. Postoperative follow-up was performed to evaluate whether the patients had new infarction, stent patency and embolization effect. Platelet count and activated partial thromboplastin time (APTT).) were measured 1 day before and 3 days after operation. Glasgow outcome score (GOS) was used to evaluate the clinical prognosis of the patients. Results 34 aneurysms and 32 aneurysms were found in 31 patients. After operation, 7 cases recurred after embolization of aneurysm, 1 case had urinary hemorrhage, no retroperitoneal hemorrhage, gastrointestinal bleeding, and no new cerebral infarction and thromboembolism occurred after operation. GOS score was 鈮，
本文编号：2460052
[Abstract]:Objective to evaluate the safety and efficacy of stent-assisted embolization of aneurysm with tirofiban. Methods the clinical data of 31 patients with aneurysm treated with stent-assisted therapy were analyzed and divided into aspirin combined clopidogrel group (double antibody group, n = 18) and tirofiban group (n = 13). The tirofiban group began to use tirofiban after half-release or complete release of the stent. Postoperative follow-up was performed to evaluate whether the patients had new infarction, stent patency and embolization effect. Platelet count and activated partial thromboplastin time (APTT).) were measured 1 day before and 3 days after operation. Glasgow outcome score (GOS) was used to evaluate the clinical prognosis of the patients. Results 34 aneurysms and 32 aneurysms were found in 31 patients. After operation, 7 cases recurred after embolization of aneurysm, 1 case had urinary hemorrhage, no retroperitoneal hemorrhage, gastrointestinal bleeding, and no new cerebral infarction and thromboembolism occurred after operation. GOS score was 鈮，
本文编号：2460052
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