外周血血脂水平与老年帕金森病患者临床特征的相关性

发布时间：2019-04-19 07:32

【摘要】：目的该探讨外周血中血脂水平与老年帕金森病(PD)患者临床特征的相关性。方法选取100例老年PD患者作为研究组,另选同期体检的健康体检者100例作为对照组,测定两组研究对象的血脂水平并分析血脂水平与PD发病、病程及Hoehn-Yahr分级的相关性。结果研究组PD患者血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(Apo)A、Apo B水平均显著低于对照组(P均0.05)。低水平Apo A、HDL-C是影响PD患病的独立危险因素(P均0.05)。随着患者Hoehn-Yahr分级的升高,其Apo A、TG、HDL-C水平显著下降(P均0.05),不同Hoehn-Yahr分级患者TC、TG、LDL-C、Apo B比较无统计学差异(P0.05)。Apo A水平(r=-0.671,P=0.012)和HDL-C水平(r=-0.689,P=0.018)与PD病程呈负相关;Apo A水平(r=-0.646)和HDL-C水平(r=-0.754)与PD患者Hoehn-Yahr分级呈负相关(P0.05)。结论血脂水平下降可增加PD患病的风险,尤以Apo A、HDL-C下降对PD病情的影响最明显,低脂血症在PD的发生发展中可能扮演了重要角色。
[Abstract]:Objective to investigate the correlation between blood lipid levels in peripheral blood and clinical characteristics in elderly patients with Parkinson's disease (PD). Methods A total of 100 elderly patients with PD were selected as the study group and 100 healthy subjects as the control group. The blood lipid levels of the two groups were measured and the correlation between the serum lipid levels and the incidence, course of disease and Hoehn-Yahr grade of the two groups were analyzed. Results the serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) A, in patients with PD were studied. The level of Apo B was significantly lower than that of the control group (P 0.05). Low level of Apo A and HDL C were independent risk factors for PD (P 0.05). The levels of Apo A, TG and HDL C decreased significantly with the increase of Hoehn-Yahr grade (all P 0.05). The TC,TG,LDL-C, of patients with different Hoehn-Yahr grades was significantly decreased (P < 0.01). There was no significant difference in Apo B (P0.05). Apo A level (r = 0.671, P = 0.012) and HDL-C level (r = 0.689, P = 0.018). There was a negative correlation between the level of HDL-C (r = 0.689, P = 0.018) and the course of PD. The levels of Apo A (r = 0.646) and HDL-C (r = 0.754) were negatively correlated with the Hoehn-Yahr grade of PD patients (P0.05). Conclusion the decrease of blood lipid level can increase the risk of PD, especially Apo A, the decrease of HDL / C has the most obvious effect on the disease of PD. Hypolipoidemia may play an important role in the occurrence and development of PD. [WT5 "HZ] conclusion [WT5" BZ] [WT5 "BZ]
【作者单位】：徐州医学院附属医院神经内科;
【分类号】：R742.5

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