偏头痛患者血清hs-CRP及HCY的测定及偏头痛发病机制的探讨

发布时间：2019-04-19 07:46

【摘要】：目的:偏头痛是可以直接导致脑梗死的慢性神经血管性疾病,且发病机制尚不十分清楚,而近年来大量的研究表明偏头痛与缺血性脑卒中患病风险的增高显著相关,但具体关联机制目前尚不明确。此次试验通过观察卒中风险评价指标hs-CRP和卒中危险因子HCY在偏头痛患者血循环内含量的变化,从新的角度探讨偏头痛的发病机制,从而提供新的防治策略。方法:偏头痛组选自2016年10月至2017年01月在山西省人民医院就诊的偏头痛患者24例,均为无先兆偏头痛患者,其中偏头痛发作期患者10例,偏头痛缓解期患者14例;健康对照组选自于本院体检中心以及健康志愿者,共23例。偏头痛组及对照组均空腹8h后于清晨抽取血液样本,标本经抗凝,离心,取上层血清分析。采用散射比浊法测定血hs-CRP的含量,采用速率法测定血HCY的含量。采用SPSS16.0软件进行数据统计分析。结果:1.血清hs-CRP的含量(mg/L)(结果采用Me±QR描述):偏头痛发作期患者(10例)3.65±1.14,缓解期患者(14例)2.21±0.81,对照组(23例)0.77±0.33,发作期及缓解期患者均与对照组比较,均P0.05;发作期与缓解期比较,P0.05;2.血清HCY含量(umol/L)(结果采用Me±QR描述):偏头痛组(24例)20.53±2.90,对照组(23例)11.89±3.31,偏头痛组与对照作比较,P0.05。结论:1.偏头痛缓解期患者血清hs-CRP较对照组升高,提示偏头痛患者在缓解期也存在炎症状态;发作期患者血清hs-CRP较缓解期进一步升高,支持偏头痛发作期伴随炎性因子的释放;2.偏头痛组患者血HCY高于对照组,提示HCY的升高可能参与偏头痛的发病机制;3.偏头痛患者血清hs-CRP及HCY高于对照组,推测二者可能系偏头痛与缺血性脑卒中潜在的关联机制之一。
[Abstract]:Objective: migraine is a chronic neurovascular disease that can directly lead to cerebral infarction, and the pathogenesis of migraine is not very clear. In recent years, a large number of studies have shown that migraine is significantly related to the increased risk of ischemic stroke. However, the specific linkage mechanism is not clear at present. By observing the changes of stroke risk assessment index hs-CRP and stroke risk factor HCY in blood circulation of migraine patients, this study explored the pathogenesis of migraine from a new point of view, so as to provide new strategies for prevention and treatment of migraine. Methods: from October 2016 to January 2017, 24 migraine patients in Shanxi Provincial people's Hospital were enrolled in the migraine group. All patients were migraine patients without premonitory symptoms, including 10 migraine patients in attack period and 14 migraine patients in remission period. The healthy control group was selected from the physical examination center of our hospital and healthy volunteers, a total of 23 cases. The blood samples were taken in the morning after 8 hours fasting in both the migraine group and the control group. The samples were analyzed by anticoagulation centrifugation and upper layer serum analysis. The content of hs-CRP in blood was determined by nephelometry and the content of HCY in blood was determined by rate method. The data were analyzed by SPSS16.0 software. Results: 1. Serum hs-CRP content (mg/L) (results described by Me 卤QR): migraine attack (10 cases) (3.65 卤1.14), remission (14 cases) 2.21 卤0.81, control group (23 cases) 0.77 卤0.33, The patients in paroxysmal stage and remission stage were compared with the control group (P 0.05). Compared with the remission stage, P0.05m2. Serum HCY content (umol/L) (results described by Me 卤QR): 20.53 卤2.90,11.89 卤3.31in the control group (n = 23) and 20.53 卤2.90in the control group (n = 24). Compared with the control group, the patients with migraine pain were compared with the control group (P 0.05). Conclusions: 1. The levels of serum hs-CRP in migraine patients in remission stage were higher than those in control group, suggesting that migraine patients also had inflammatory state in remission stage, and serum hs-CRP in patients with paroxysmal migraine was further higher than that in remission stage, which supported the release of inflammatory factors in migraine paroxysmal phase. 2. The level of serum HCY in migraine group was higher than that in control group, suggesting that the increase of HCY might be involved in the pathogenesis of migraine. The levels of serum hs-CRP and HCY in migraine patients were higher than those in control group, which suggested that they might be one of the potential mechanisms of migraine and ischemic stroke.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R747.2

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