阿托伐他汀联合苯磺酸氨氯地平治疗脑梗死的临床效果研究

发布时间：2019-04-21 10:55

【摘要】：目的研究脑梗死应用阿托伐他汀与苯磺酸氨氯地平联合治疗的效果。方法将脑梗死患者66例随机分为A组与B组各33例。A组予以常规治疗加苯磺酸氨氯地平,B组在A组治疗基础上加用阿托伐他汀,比较2组疗效。结果治疗后B组的血清总胆固醇(Total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)明显低于A组(P0.05),日常生活能力量表(activity of daily life scale,ADL)评分明显高于A组而美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分明显低于A组(P0.05);B组总有效率为93.94%,明显高于A组的78.79%(P0.05)。A组11例治愈,10例显效,5例有效,7例无效,总有效率为78.79%。B组24例治愈,4例显效,3例有效,2例无效,总有效率为93.94%。B组的有效率明显高于A组(χ2=8.501,P=0.0030.05)。结论阿托伐他汀与苯磺酸氨氯地平联合治疗脑梗死能够调节血脂代谢、改善神经功能缺损及生活活动能力、提高临床疗效。
[Abstract]:Objective to study the effect of Atto vastatin combined with amlodipine benzenesulfonate in the treatment of cerebral infarction. Methods 66 patients with cerebral infarction were randomly divided into group A (n = 33) and group B (n = 33). Group A was treated with routine therapy plus amlodipine benzenesulfonate, group B was treated with Atto vastatin on the basis of group A, and the curative effects were compared between the two groups. Results after treatment, serum total cholesterol (Total cholesterol,TC), triglyceride (triglyceride,TG) and low density lipoprotein cholesterol (low density lipoprotein cholesterol,LDL-C) in group B were significantly lower than those in group A (P0.05). The activity of daily living scale (activity of daily life scale,) was significantly lower in group B than in group A (P0.05). The scores of ADL were significantly higher in group A than those in group A, while the scores of (National Institutes of Health Stroke Scale,NIHSS in NIH stroke scale were significantly lower than those in group A (P0.05). The total effective rate of group B was 93.94%, which was significantly higher than that of group A (78.79%) (P0.05:). A group: 11 cases were cured, 10 cases were significantly effective, 5 cases were effective, 7 cases were ineffective, the total effective rate was 78.79%, 24 cases in group B were cured, 4 cases were significantly effective. The total effective rate in group B was 93.94%. The effective rate in group B was significantly higher than that in group A (蠂 2 = 8.501, P = 0.0030.05). Conclusion Atto vastatin combined with amlodipine benzenesulfonate in the treatment of cerebral infarction can regulate blood lipid metabolism, improve neurological impairment and activity of life, and improve the clinical efficacy.
【作者单位】：阿克苏地区第一人民医院神经内科;
【分类号】：R743.33

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