脑得康治疗进展性脑卒中的临床疗效及对血清炎性因子水平的影响

发布时间：2019-04-22 20:12

【摘要】：目的探讨脑得康治疗进展性脑卒中(PIS)的临床疗效及对炎性因子血清学水平的影响。方法 98例PIS患者根据随机数字表法分为对照组和观察组,各49例,两组均进行常规治疗,观察组在此基础上加用脑得康丸,8 w为1个疗程。观察并对比两组的临床疗效、神经功能缺损程度[美国国立卫生研究院脑卒中量表(NIHSS)评分]和日常生活能力[日常生活活动能力量表(ADL)评分]以及血清炎性因子水平。结果观察组的临床效果显著高于对照组(P0.05)。治疗8 w时两组NIHSS评分均显著降低,ADL评分均显著升高且观察组与对照组相比(P0.05)。治疗后4、8 w时观察组血清白细胞介素(IL)-6、超敏C反应蛋白(hs-CRP)水平均显著低于对照组,血清雌二醇(E2)水平显著高于对照组(P0.05)。结论脑得康可改善SIP患者神经功能、日常生活能力,抑制血清IL-6、hs-CRP水平并升高血清E2水平,治疗效果较好。
[Abstract]:Objective to investigate the clinical efficacy of Naodekang in the treatment of (PIS) in patients with progressive stroke and its effect on the serum level of inflammatory factors. Methods 98 patients with PIS were divided into control group (n = 49) and observation group (n = 49) according to the method of random number table. All patients in the two groups were treated with routine therapy. On this basis, the observation group was given Naokang pills for 8 weeks as a course of treatment. To observe and compare the clinical efficacy, neurological impairment (NIHSS) score of NIH Stroke scale), ADL (activity of Daily living scale (ADL) score) and serum inflammatory factor level between the two groups. Results the clinical effect of the observation group was significantly higher than that of the control group (P0.05). At the 8th week after treatment, the NIHSS scores of the two groups were significantly decreased, the ADL scores were significantly increased, and the observation group was compared with the control group (P0.05). The levels of serum interleukin-6 (IL)-6) and hypersensitive C-reactive protein (hs-CRP) in the observation group were significantly lower than those in the control group at the 4th and 8th week after treatment, and the serum estradiol (E2) level was significantly higher than that in the control group (P0.05). Conclusion Naodekang can improve the neurological function, activity of daily living (ADL), inhibit the level of serum IL-6,hs-CRP and increase the level of serum E _ 2 in patients with SIP. The therapeutic effect is better.
【作者单位】：胶州市人民医院神经外二科;
【基金】：青岛市卫生科技指导项目(2015WJZD145)
【分类号】：R743.3

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