189例帕金森病直立性低血压发生率及相关危险因素临床分析

发布时间：2019-05-28 23:00

【摘要】：目的调查帕金森病(PD)患者直立性低血压(OH)的发生率,并进一步探讨OH的相关危险因素。方法对189例PD患者(PD组)及156例健康志愿者(对照组)进行清晨醒后卧立位血压的测量,采用自主神经症状量表(SCOPA-AUT)进行自主神经功能评估,对PD患者OH发生率及相关危险因素进行统计学分析。结果 PD组SCOPA-AUT评分明显高于对照组(P0.01);PD组清晨醒后卧位收缩压、舒张压均高于对照组(P0.05),PD组立位收缩压较卧位明显下降(P0.01);PD组OH的发生率为31.75%,明显高于对照组的12.18%(P0.01);PD组OH的发生与年龄、抗帕金森病药物的服用剂量正相关(P0.01)。结论 PD患者存在明显的自主神经功能障碍;PD患者清晨醒后立位收缩压明显下降;PD患者OH的发生率较高;高龄、大剂量的抗帕金森药物是PD患者发生OH的危险因素。
[Abstract]:Objective to investigate the incidence of orthostatic hypotension (OH) in patients with Parkinson's disease (PD) and to explore the risk factors of OH. Methods the standing blood pressure of 189 patients with PD (PD group) and 156 healthy volunteers (control group) were measured after waking up in the morning, and the autonomic nervous function was evaluated by autonomic nervous symptoms scale (SCOPA-AUT). The incidence of OH and related risk factors in patients with PD were statistically analyzed. Results the SCOPA-AUT score in PD group was significantly higher than that in control group (P 0.01). The systolic blood pressure and diastolic blood pressure in lying position in); PD group were significantly higher than those in control group (P 0.05). The systolic blood pressure in vertical position in), PD group was significantly lower than that in lying position (P 0.01). The incidence of OH in PD group was 31.75%, which was significantly higher than that in control group (P 0.01). The incidence of OH in); PD group was positively correlated with age and dose of anti-Parkinson's disease drugs (P 0.01). Conclusion PD patients have obvious autonomic nervous dysfunction, PD patients wake up in the morning and systolic blood pressure is significantly decreased; the incidence of OH in PD patients is high. High dose of anti-Parkinson's drugs is a risk factor for OH in patients with PD.
【作者单位】：郑州大学第一附属医院神经内科;
【分类号】：R742.5

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