进展性脑梗死患者血清HMGB1、FKN动态变化研究

发布时间：2019-05-28 10:24

【摘要】：目的探讨高迁移率族蛋白B1(HMGB1)及不规则趋化因子(FKN)在进展性脑梗死中的可能作用机制。方法用酶联免疫吸附试验(ELISA)法检测急性脑梗死患者不同时期血清HMGB1及FKN水平变化,根据斯堪的纳维亚脑卒中量表(scandinavian stroke scale,SSS)评分分为进展组和非进展组。根据梗死体积将180例患者分为大梗死灶组、中梗死灶组、小梗死灶组。另纳入30例健康体检者作为对照组。结果 180例急性脑梗死患者中有35例(19.44%)发展为进展性脑梗死。进展组SSS基线评分低于非进展组,差异有统计学意义(P0.05)。进展性组患者发病后1 d、7 d、14 d血清HMGB1、FKN水平高于非进展组和对照组,有统计学意义(P0.05)。梗死灶体积大则血清HMGB1、FKN水平高(P0.05)。结论血清HMGB1、FKN增加可能通过增加炎症反应促进动脉粥样硬化形成和进展,加重脑组织损伤,导致脑梗死患者病情进展。
[Abstract]:Objective to investigate the possible mechanism of high mobility group protein B1 (HMGB1) and irregular chemokine (FKN) in progressive cerebral infarction. Methods the changes of serum HMGB1 and FKN levels in patients with acute cerebral infarction were detected by enzyme linked immunosorbent assay (ELISA). According to the Scandinavian Stroke scale (scandinavian stroke scale,SSS) score, the patients were divided into progressive group and non-progressive group. According to the infarction volume, 180 patients were divided into large infarction group, middle infarction group and small infarction group. Another 30 healthy subjects were included as the control group. Results 35 (19.44%) of 180 patients with acute cerebral infarction developed progressive cerebral infarction. The baseline score of SSS in the progressive group was lower than that in the non-progressive group, and the difference was statistically significant (P 0.05). The serum HMGB1,FKN level in the progressive group was significantly higher than that in the non-progressive group and the control group on the 1st day, 7th day and 14th day after onset (P 0.05). The serum HMGB1,FKN level was higher when the infarction volume was large (P 0.05). Conclusion the increase of serum HMGB1,FKN may promote the formation and progress of atherosclerosis and aggravate the injury of brain tissue by increasing inflammatory reaction, which may lead to the progress of cerebral infarction.
【作者单位】：佳木斯大学附属第一医院神经内科;
【分类号】：R743.33

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