小脑顶核电刺激对脑白质疏松患者执行功能的改善效果

发布时间：2019-06-04 11:05

【摘要】：目的观察小脑顶核电刺激(FNS)对脑白质疏松(LA)患者执行功能的改善效果。方法将33例LA伴执行功能障碍的患者随机分为观察组17例和对照组16例。两组均给予常规药物治疗,包括针对LA给予脑蛋白水解物护脑治疗,针对合并的基础疾病给予对症治疗,治疗20 d。观察组在常规治疗基础上采用FNS治疗,对患者小脑顶核进行仿生电刺激,电流1 m A,频率130~200 Hz,强度为70~100 m V,每次30 min,1次/d,连续治疗20d。分别于治疗前后对两组患者进行执行功能评价,包括Stroop色词测试C部分(SCWT-C)、言语流畅性测试(VFT)、连线测试A部分和连线测试B部分(TMT-A、B)、画钟测验(CDT);进行头颅MRI检查,测算执行功能相关脑区白质部分各向异性(FA)值。结果对照组治疗前后各项执行功能测试成绩差异无统计学意义。观察组FNS治疗后SCWT-C、VFT、TMT-A及TMT-B、CDT的测试成绩较治疗前有所提高(P均0.05),且观察组治疗后各项执行功能测试成绩优于对照组治疗后(P均0.05)。对照组治疗前后执行功能相关脑区白质FA值差异无统计学意义。观察组治疗后右额叶白质、左额叶白质、右顶叶白质、左顶叶白质、右扣带束、左扣带束的FA值均高于治疗前,且高于对照组治疗后(P均0.05)。结论 FNS治疗可提高LA患者的执行功能,改善执行功能相关脑区皮层下白质纤维微结构的完整性。
[Abstract]:Objective to observe the effect of cerebellar fastigial nucleus stimulation (FNS) on executive function in patients with white matter osteoporosis (LA). Methods 33 patients with LA with executive dysfunction were randomly divided into observation group (n = 17) and control group (n = 16). Both groups were treated with routine drugs, including brain protein hydrolysate for LA, symptomatic treatment for basic diseases, treatment for 20 days. On the basis of routine treatment, the patients in the observation group were treated with FNS. The cerebellar fastigial nucleus was stimulated by bionic electrical stimulation. The current was 1 Ma, the frequency was 130 鈮，

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