症状性颈动脉狭窄患者延长双联抗血小板治疗临床观察
发布时间：2019-06-25 09:00
【摘要】：目的探讨双联抗血小板时间对症状性颈动脉狭窄患者缺血性卒中复发和动脉斑块活动性的影响。方法症状性颈动脉狭窄患者95例,根据发病后双联抗血小板的持续时间,分为短期双联抗血小板(SD)组(疗程1月)67例及延长双联抗血小板(PD)组(疗程3月)28例,2组患者的临床资料、MES、血清MMP-7和hs-CRP水平等基线数据的差别无统计学意义。分析并比较2组患者经双联抗血小板治疗后,脑卒中复发、出血并发症、经颅多普勒超声检测微栓子(MES)、血清基质金属蛋白酶-7(MMP-7)和超敏C反应蛋白(hs-CRP)水平的差别。结果 (1)随访6月后,SD组的MES阳性率及血清MMP-7、hs-CRP水平分别为(38.8%,26/67),(17.35±0.95)μg/L和(13.74±1.41)mg/L,均低于入院时水平(P0.05);PD组的MES阳性率及血清MMP-7、hs-CRP水平分别为(17.9%,5/28),(16.94±0.62)μg/L和(13.05±1.03)mg/L,均低于入院时水平(P0.05),且均低于SD组(P0.05)。(2)随访1年后,2组的脑梗死或短暂性脑缺血发作复发和出血并发症的差别无统计学意义(P0.05)。结论 PD治疗可减少症状性颈动脉狭窄患者的MES,可能有利于降低缺血性卒中的复发率。
[Abstract]:Objective to investigate the effect of dual antiplatelet time on ischemic stroke recurrence and plaque activity in patients with symptomatic carotid stenosis. Methods according to the duration of double antiplatelet after onset, 95 patients with symptomatic carotid artery stenosis were divided into short-term double antiplatelet (PD) group (n = 67) and extended double antiplatelet (PD) group (n = 28). There was no significant difference in MES, serum MMP-7 and hs-CRP levels between the two groups. After double antiplatelet therapy, the recurrence of stroke and bleeding complications were analyzed and compared. The levels of serum matrix metalloprotease-7 (MMP-7) and high-sensitive C-reactive protein (hs-CRP) in microemboli (MES), were detected by transcranial Doppler ultrasound. Results (1) after 6 months follow-up, the positive rate of MES and the level of serum MMP-7,hs-CRP in SD group were (38.8%), 26 鈮，
本文编号：2505563
[Abstract]:Objective to investigate the effect of dual antiplatelet time on ischemic stroke recurrence and plaque activity in patients with symptomatic carotid stenosis. Methods according to the duration of double antiplatelet after onset, 95 patients with symptomatic carotid artery stenosis were divided into short-term double antiplatelet (PD) group (n = 67) and extended double antiplatelet (PD) group (n = 28). There was no significant difference in MES, serum MMP-7 and hs-CRP levels between the two groups. After double antiplatelet therapy, the recurrence of stroke and bleeding complications were analyzed and compared. The levels of serum matrix metalloprotease-7 (MMP-7) and high-sensitive C-reactive protein (hs-CRP) in microemboli (MES), were detected by transcranial Doppler ultrasound. Results (1) after 6 months follow-up, the positive rate of MES and the level of serum MMP-7,hs-CRP in SD group were (38.8%), 26 鈮，
本文编号：2505563
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