复合动作电位与迷走神经刺激个性化参数调控

发布时间：2019-06-29 20:10

【摘要】：迷走神经刺激(VNS)广泛应用于癫痫和抑郁等多种药物难治性疾病的治疗,实现VNS个性化调控对疗法的临床推广具有重要意义。该文提出了以术中复合动作电位(CAP)为评估依据的VNS疗法个性化参数选择方法。搭建了CAP信号采集平台,开展了中华小型猪的活体实验,在恒流刺激模式下分析了电流幅度、脉宽和频率等VNS刺激参数与迷走神经CAP信号的量化关系,明确了VNS疗法临床常用刺激参数的选择依据,进而提出了个性化治疗参数的选择标准及选择范围。实验结果表明:应以CAP信号中A类纤维和B类纤维的不同响应特性为依据,开展VNS治疗癫痫和抑郁的个性化参数调控。该方法为VNS疗效的提高以及闭环VNS疗法的发展奠定了基础。
[Abstract]:Vagus nerve stimulation (VNS) is widely used in the treatment of intractable diseases such as epilepsy and depression. It is of great significance to realize the individualized regulation of VNS for the clinical promotion of therapy. In this paper, a personalized parameter selection method for VNS therapy based on intraoperative compound action potential (CAP) is proposed. The CAP signal acquisition platform was built and the in vivo experiment of Chinese miniature pigs was carried out. The quantitative relationship between VNS stimulation parameters such as current amplitude, pulse width and frequency and vagus nerve CAP signal was analyzed under constant current stimulation mode. The selection basis of clinical stimulation parameters of VNS therapy was clarified, and then the selection standard and selection range of personalized treatment parameters were put forward. The results showed that the individualized parameter regulation of VNS in the treatment of seizures and depression should be carried out based on the different response characteristics of Class A fibers and Class B fibers in CAP signals. This method lays a foundation for the improvement of the curative effect of VNS and the development of closed-loop VNS therapy.
【作者单位】：清华大学航天航空学院;北京脑重大疾病研究院癫痫研究所;清华-伯克利深圳学院;
【基金】：国家自然科学基金大仪器专项(81527901) 国家青年科学基金项目(51407103;61601258) 中央在京高校重大成果转化项目国家重点研发计划项目(2016YFC0105900);国家重点研发计划课题(2016YFC0105502)
【分类号】：R741

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