缺血性脑卒中和短暂性脑缺血发作患者血清miR-23b-3p水平变化的比较研究
发布时间:2021-11-23 19:45
目的探讨短暂性脑缺血发作(transient ischemic attack, TIA)患者和缺血性脑卒中(ischemic stroke, IS)患者血清miR-23b-3p的水平变化。方法选取常州市第一人民医院神经内科2017年8月~2019年4月收治的156例IS患者,71例TIA患者和85例常规体检的健康对照者纳入研究。采用实时荧光定量PCR(quantitative reverse-transcription PCR, qRT-PCR)技术检测受试者血清miR-23b-3p水平并分析相关生化指标。结果与健康对照组相比,IS组(t=4.517,P<0.001)及TIA患者组(t=2.728, P<0.001)血清miR-23b-3p水平均显著升高,且IS组高于TIA患者组(t=3.364,P=0.043)。此外,重度IS组miR-23b-3p水平明显高于中度IS(t=1.212,P=0.034)和轻度IS组(t=4.931, P<0.001),差异均有统计学意义。相关性分析显示IS患者血清miR-23b-3p水平与美国国立卫生研究院卒中量表(National ...
【文章来源】:现代检验医学杂志. 2020,35(05)
【文章页数】:5 页
【部分图文】:
IS患者和TIA患者血清mi R-23b-3p水平
【参考文献】:
期刊论文
[1]Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy[J]. Chase Kingsbury,Matt Heyck,Brooke Bonsack,Jea-Young Lee,Cesar V.Borlongan. Neural Regeneration Research. 2020(06)
[2]MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression[J]. Bridget Martinez,Philip V Peplow. Neural Regeneration Research. 2020(04)
[3]循环微小RNA在静脉血栓栓塞症中的研究进展[J]. 常运鹤,王庆贤. 中华实验外科杂志. 2019 (02)
[4]颈动脉粥样硬化斑块性质与患者血清miRNA-126,miRNA-155水平的相关性研究[J]. 姜彦峰,李小侠,陈安志. 现代检验医学杂志. 2017(06)
本文编号:3514533
【文章来源】:现代检验医学杂志. 2020,35(05)
【文章页数】:5 页
【部分图文】:
IS患者和TIA患者血清mi R-23b-3p水平
【参考文献】:
期刊论文
[1]Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy[J]. Chase Kingsbury,Matt Heyck,Brooke Bonsack,Jea-Young Lee,Cesar V.Borlongan. Neural Regeneration Research. 2020(06)
[2]MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression[J]. Bridget Martinez,Philip V Peplow. Neural Regeneration Research. 2020(04)
[3]循环微小RNA在静脉血栓栓塞症中的研究进展[J]. 常运鹤,王庆贤. 中华实验外科杂志. 2019 (02)
[4]颈动脉粥样硬化斑块性质与患者血清miRNA-126,miRNA-155水平的相关性研究[J]. 姜彦峰,李小侠,陈安志. 现代检验医学杂志. 2017(06)
本文编号:3514533
本文链接:https://www.wllwen.com/yixuelunwen/shenjingyixue/3514533.html
最近更新
教材专著