岛叶癫痫术前综合定位及基于脑磁图的高频振荡源定位及脑网络研究
发布时间：2021-12-23 16:18
岛叶癫痫（insular epilepsy）临床上可以表现出类似额叶癫痫、颞叶癫痫及顶叶癫痫的症状。岛叶癫痫临床的复杂性和变异性常常很难判定岛叶皮层独立致痫性的存在,是一些手术失败的原因。岛叶本身及其与其他潜在致痫区（epileptogenic zones,EZ）的广泛联系导致症状的复杂多样和诊断的不确定性甚至误诊,仅凭临床症状诊断岛叶癫痫具有挑战性。颅内电极脑电图（Intracranial electroencephalography,ICEEG）,尤其是立体定向脑电图（stereo-electroencephalography,SEEG）通过解剖-电生理-临床模式被用于确认岛叶皮层放电起源定位致痫灶。但是ICEEG是侵袭性的具有一定风险的检查。而且ICEEG监测其最主要劣势在于空间覆盖有限,只有有限数量的电极能够被置入。脑磁图（Magnetoencephalography,MEG）,能够无创性的探测大脑神经电磁信号,是一种相对较新的脑功能的检测技术,脑磁图与传统脑电图（electroencephalography,EEG）相比其具有更高的空间分辨率,与功能核磁共振（function...
【文章来源】：河北医科大学河北省
【文章页数】：118 页
【学位级别】：博士
【部分图文】：
岛叶癫痫MEG棘波源定位图像
图 2 头皮 EEG, MRI, MEG, ICEEG 定位致痫区Fig.2 Localization of epileptogenic zone with scalp EEG, MRI, MEG andICEEG. Ictal scalp EEG showed low amplitude spikes over Sph-L, F7, T5 (Ain patient 19. Preoperative MRI showed no signal abnormalities (B). MEGraw data and tsss data (C). Source localization of MEG data with sECDdemonstrated left insular origination (D). Both interictal (E) and ictal (FICEEG captured epileptic activity arising from the left insula and cingulatgyrus..
图 1 不同 MEG 方法溯源岛叶癫痫致痫区g. 1 Source localization of epileptogenic zone by two MEG. methodtients with insular epilepsy. MEG raw data and tsss data in patient 10 ) Field contours and source (side view) and sensor waveform (top viw and processed data for another definitive MEG spike originating frofferent source (C); the related field contours and sensor waveforms urce localization by MEG with sECD using approximately 60 minuteta demonstrated two tight dipole clusters, located in the insular opercu). However, source localization by MEG with accumulated source ima HFOs during the above spikes showed local origination in the insula (F)
【参考文献】：
期刊论文
[1]脑磁图在岛叶癫癇诊断中的应用:八例报告并文献复习[J]. 李哲,刘晓云,姚兴祺,毛薇,张夏婷,杜薇,朴媛媛,陶蔚,遇涛,吴逊,王玉平,孙伟. 中国现代神经疾病杂志. 2014(11)
本文编号：3548794
【文章来源】：河北医科大学河北省
【文章页数】：118 页
【学位级别】：博士
【部分图文】：
岛叶癫痫MEG棘波源定位图像
图 2 头皮 EEG, MRI, MEG, ICEEG 定位致痫区Fig.2 Localization of epileptogenic zone with scalp EEG, MRI, MEG andICEEG. Ictal scalp EEG showed low amplitude spikes over Sph-L, F7, T5 (Ain patient 19. Preoperative MRI showed no signal abnormalities (B). MEGraw data and tsss data (C). Source localization of MEG data with sECDdemonstrated left insular origination (D). Both interictal (E) and ictal (FICEEG captured epileptic activity arising from the left insula and cingulatgyrus..
图 1 不同 MEG 方法溯源岛叶癫痫致痫区g. 1 Source localization of epileptogenic zone by two MEG. methodtients with insular epilepsy. MEG raw data and tsss data in patient 10 ) Field contours and source (side view) and sensor waveform (top viw and processed data for another definitive MEG spike originating frofferent source (C); the related field contours and sensor waveforms urce localization by MEG with sECD using approximately 60 minuteta demonstrated two tight dipole clusters, located in the insular opercu). However, source localization by MEG with accumulated source ima HFOs during the above spikes showed local origination in the insula (F)
【参考文献】：
期刊论文
[1]脑磁图在岛叶癫癇诊断中的应用:八例报告并文献复习[J]. 李哲,刘晓云,姚兴祺,毛薇,张夏婷,杜薇,朴媛媛,陶蔚,遇涛,吴逊,王玉平,孙伟. 中国现代神经疾病杂志. 2014(11)
本文编号：3548794
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