细胞膜片技术在组织工程中的应用与研究进展

发布时间：2018-01-02 04:09

本文关键词：细胞膜片技术在组织工程中的应用与研究进展　出处：《中国组织工程研究》2016年11期 　论文类型：期刊论文

【摘要】：背景:细胞膜片技术无须支架材料和酶消化,通过刺激细胞外基质分泌形成致密膜片组织,能有效地修复组织缺损和改善器官功能。目的技术和新进展,为相关基础和临床研究:回顾近年来国内外细胞膜片技术应用于组织工程领域的新提供新的思路。方法:由第一作者检索CNKI全文数据库、万方数据库及PubM ed数据库2010年1月至2015年7月的相关文献,检索关键词为"细胞膜片,组织工程;cell sheet,tissue engineering"。结果与结论:与传统细胞膜片技术相比,支架材料与细胞膜片技术相整合用于重建和修复坚韧组织器官,多层细胞膜片相互层叠形成三维组织修复软组织器官等新技术不断涌现。与单层细胞膜片相比,通过相同或不同的细胞片层叠而成的3D细胞膜片具有更强组织再生功能,而且在体外就能构建出理想的靶组织模型。利用支架材料复合细胞膜片技术来提高复合物机械强度和减少细胞流失,并用于牙齿、骨与软骨等机体坚韧组织修复取得较大进展。目前细胞膜片技术仍主要处于实验室研究阶段,临床应用研究不多,期待有更多的创新性手段融入到细胞膜片技术上来。
[Abstract]:Background: membrane technology can effectively repair tissue defect and improve organ function by stimulating extracellular matrix secretion to form dense membrane tissue without scaffold material and enzyme digestion. To provide new ideas for the application of cell membrane technology in tissue engineering in recent years. Methods: the CNKI full-text database was searched by the first author. From January 2010 to July 2015 in Wanfang database and PubM ed database, the key words were "cell membrane, tissue engineering;" Cell sheettte engineering ". Results and conclusions: compared with traditional cell membrane technology. Scaffold materials are integrated with cell membrane technology to reconstruct and repair tough tissues and organs, and new techniques such as multi-layer membrane lamination to form three-dimensional tissue and soft tissue repair are emerging, compared with monolayer cell membrane. The 3D cell membrane slices, which are stacked by the same or different cell pieces, have stronger tissue regeneration function. Moreover, the ideal target tissue model could be constructed in vitro. The scaffold composite cell membrane technology was used to improve the mechanical strength of the composite and reduce cell loss, and used in teeth. Great progress has been made in the repair of tough tissues, such as bone and cartilage. At present, cell membrane technology is still mainly in the laboratory research stage, clinical application research is not much. Look forward to more innovative approaches to cell membrane technology.
【作者单位】：上海交通大学附属第六人民医院泌尿外科;
【基金】：2012国家自然科学基金面上项目(81270780):负载VEGF的磁性量子点结合细胞膜片技术构建组织工程尿道的实验研究~~
【分类号】：R318
【正文快照】： 文章快速阅读:细胞膜片技术在组织工程中应用研究进展第一作者以“细胞膜片技术,再生医学,血管共检索到中英文文献363余篇排除研究目的与本文无关及重复文献化”检索CNKI数据库、万方数据库、Pubmed数纳入有关细胞膜片技术应用据库2010年1月至通过阅读摘要初步筛选,共选取29篇

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