冻干血小板和冻干冷沉淀在新西兰白兔耳动脉出血中的应用分析

发布时间：2018-01-04 08:25

本文关键词：冻干血小板和冻干冷沉淀在新西兰白兔耳动脉出血中的应用分析　出处：《中国输血杂志》2015年01期 　论文类型：期刊论文

【摘要】：目的建立新西兰白兔耳动脉出血动物模型,探讨冻干血小板(FDP)和冻干冷沉淀(FDC)在新西兰白兔耳动脉出血中的止血效果。方法新西兰白兔32只,随机分为4组:FDP组、FDC组、冻干血小板及冻干冷沉淀联合组(FDPC)及空白对照组(BC),每组8只,建立耳动脉出血模型,并将止血材料敷于新西兰白兔出血创面,观察各组的止血时间及失血量。结果对于耳动脉出血,各组均可止血,FDP组、FDC组及FDPC组的止血时间和出血量均明显少于BC组,差异有统计学意义(P0.05);而FDP组与FDC组间止血时间及失血量差异显著(P0.05);与单独使用FDP或FDC相比,FDPC组止血时间显著性缩短,失血量明显减少,差异有统计学意义(P0.05)。结论 FDP和FDC联合使用对新西兰白兔耳动脉出血具有更显著的止血效果。
[Abstract]:Objective to establish an animal model of auricular artery hemorrhage in New Zealand white rabbits. To investigate the hemostatic effect of freeze-dried platelets (FDP) and freeze-dried cryoprecipitation (FDC) on auricular artery hemorrhage in New Zealand white rabbits. Methods Thirty-two New Zealand white rabbits were randomly divided into 4 groups: FDC group (n = 4) and FDC group (n = 4). Freezing dried platelets and freeze-dried cryoprecipitation combined group (FDPC) and blank control group (8 rats in each group) were used to establish an auricular artery hemorrhage model and the hemostatic materials were applied to the bleeding wounds of New Zealand white rabbits. Results for auricular artery hemorrhage, the hemostasis time and the amount of bleeding in FDC group and FDPC group were significantly lower than those in BC group. The difference was statistically significant (P 0.05). The difference of hemostatic time and blood loss between FDP group and FDC group was significant (P 0.05). Compared with FDP or FDC alone, the hemostasis time was significantly shortened and the amount of blood loss was significantly decreased in the group treated with FDP or FDC alone. Conclusion the combination of FDP and FDC has a more significant hemostatic effect on auricular artery hemorrhage in New Zealand white rabbits.
【作者单位】：南方医科大学;广州军区广州总医院输血科;
【基金】：国家科技重大专项课题(2011ZXJ09104-07C)
【分类号】：R318.08
【正文快照】： 出血是战伤、创伤救治手术中病人死亡的主要原因,有效的止血能挽救病人生命,缓解创伤病人病情及改善预后[1]。近年来各种止血材料的研究和应用为外伤止血提供了一种新方法。目前,临床上应用较多的局部止血材料主要是胶原蛋白类、氧化纤维素类、甲壳素类及纤维蛋白胶等。胶原蛋

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