掺锶透钙磷石骨水泥修复家兔牙槽骨缺损的研究

发布时间：2018-01-28 01:45

本文关键词： 牙槽骨缺损掺锶透钙磷石骨保护素　出处：《安徽医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：应用掺锶5%透钙磷石骨水泥修复家兔下颌牙槽骨缺损,观察骨保护素(OPG)在缺损区的表达情况,探讨掺锶透钙磷石骨水泥作为骨缺损修复材料的可行性。健康家兔18只,随机分为3组,在家兔双侧下颌牙槽骨制作骨缺损,空白对照组缺损处不植入任何材料,透钙磷石组植入透钙磷石骨水泥,掺锶5%透钙磷石组植入掺锶5%透钙磷石骨水泥。术后每组动物分别于4、8周各处死3只,通过大体观察、CBCT、免疫组化等方法观察骨缺损的修复情况。CBCT结果显示掺锶5%透钙磷石组骨缺损8周时已基本修复,透钙磷石组骨缺损部分修复,空白对照组未完成骨缺损修复。免疫组化结果显示4周时OPG表达最高,8周时减弱。4周和8周时3组组间比较,差异有统计学意义(P0.05)。在兔下颌牙槽骨缺损修复中,掺锶5%透钙磷石成骨效果显著,能有效缩短术后的康复时间,可作修复骨缺损的材料。
[Abstract]:The mandibular alveolar bone defects in rabbits were repaired with strontium 5% transpalcified phosphate bone cement and the expression of osteoprotegerin in the defect area was observed. To explore the feasibility of strontium permeable calcium phosphate cement as bone defect repair material 18 healthy rabbits were randomly divided into 3 groups to make bone defects in bilateral mandibular alveolar bone. In the blank control group, no material was implanted in the defect, while in the calcium permeable phosphorite group, the calcium phosphate bone cement was implanted in the calcium permeable phosphorite group, and the strontium 5% calcium phosphate bone cement was implanted in the strontium 5% permeable phosphorite group. Three rats were killed at 8 weeks. The repair of bone defect was observed by general observation of CBCTand immunohistochemical method. The results of CBCT showed that the bone defect was basically repaired at 8 weeks in the group of calcium phosphos doped with strontium 5%. The results of immunohistochemistry showed that the highest expression of OPG decreased at 4 weeks and decreased at 4 weeks and decreased at 8 weeks. In the restoration of rabbit mandibular alveolar bone defect, the ossification effect of strontium 5% permeable calcium phosphate stone is remarkable, which can effectively shorten the recovery time after operation and can be used as a material for repairing bone defect.
【作者单位】：华北理工大学口腔医学院正畸科;遵化市人民医院正畸科;保定市第一中心医院口腔一科;华北理工大学口腔医学院颌面外科;
【基金】：国家自然科学基金(编号:81270965)
【分类号】：R783.1
【正文快照】： 2016-12-30接收透钙磷石是以二水磷酸氢钙为主要原料的水化产物,具有较好的生物相容性和骨传导性。但因其固化时间短,降解吸收速率过快,成骨效果很难展现出来。锶(Sr)是存在于人体内的微量元素,参与骨的代谢,促进成骨的同时又能抑制骨吸收[1-2]。研究[3]表明掺锶羟基磷灰石比

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