光学脑成像检测静息态下双侧语言皮层活动的同步性

发布时间：2018-01-31 21:55

本文关键词： 生物医学应用光学神经成像神经科学血液动力学　出处：《中国生物医学工程学报》2014年04期 　论文类型：期刊论文

【摘要】：为了研究人脑双侧语言皮层区自发活动的同步性以及与语言能力的关系,使用光学脑成像来检测具有不同语言能力的被试在语言皮层区静息态下的活动,包括皮层含氧血红蛋白和脱氧血红蛋白的自发波动。共有3组被试参加实验,包括25名自闭症儿童、12名正常儿童和20名正常成年人。采用44个光学通道,记录被试双侧额下与颞叶皮层区8 min的自发波动。在滤波及去掉全局系统成分后,计算每个左右对称通道间的时域相关系数,由此反映左右相应通道位置处皮层活动的同步性。计算每个被试双侧对称感兴趣区域(如额下皮层、颞叶皮层)的平均相关系数,并定量比较3组被试的双侧平均相关系数r。结果表明,对于颞叶语言区含氧血红蛋白的双侧相关性,自闭症儿童的(r=0.306±0.039)比正常儿童的(r=0.472±0.037)显著降低(P=0.048),儿童的比成年人的(r=0.639±0.020)显著要低(P=0.00058),成年男性的(r=0.604±0.035)比成年女性的(r=0.673±0.017)略低,但两者差异不显著(P0.05)。研究表明,光学脑成像可能提供对人脑语言皮层区网络功能定性和定量的评价。
[Abstract]:In order to study the synchronism of spontaneous activities in the bilateral language cortex of human brain and its relationship with language ability, optical brain imaging was used to detect the activities of subjects with different language abilities in the resting state of the language cortex. Three groups of participants, including 25 autistic children, participated in the study, including spontaneous fluctuations in cortical oxygenated hemoglobin and deoxyhemoglobin. In 12 normal children and 20 normal adults, spontaneous waves of 8 min in bilateral frontal and temporal cortex were recorded using 44 optical channels. Time domain correlation coefficients between each left and right symmetric channels were calculated to reflect the synchronicity of cortical activity at the location of the left and right channels, and the bilateral symmetric regions of interest (such as subfrontal cortex) were calculated. The mean correlation coefficient of temporal cortex and the bilateral mean correlation coefficient r of the three groups were compared quantitatively. The results showed that there was bilateral correlation of oxygenated hemoglobin in the temporal lobe language area. 0.306 卤0.039) in autistic children was significantly lower than that in normal children (0.472 卤0.037). Compared with that of adults, children's rhizoidae were significantly lower than that of adults (0.639 卤0.020) (P < 0.00058). In adult males, 0.604 卤0.035) was slightly lower than that in adult females (0.673 卤0.017), but the difference was not significant (P 0.05). Optical brain imaging may provide a qualitative and quantitative assessment of the function of the cortical network of the human brain.
【作者单位】：华南师范大学华南先进光电子研究院光及电磁波研究中心;
【基金】：广东省创新团队项目(201001D0104799318)
【分类号】：R310
【正文快照】： 引言功能近红外光谱(functional near-infraredspectroscopy,fNIRS)是一种新型的无创光学脑功能成像技术[1-8]。fNIRS的生理基础类似于功能性核磁共振成像(fMRI),它检测皮层血液动力学参数(包括含氧血红蛋白HBO、脱氧血红蛋白HB和总血红蛋白HBT),通过神经血管耦合机制获得皮层

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