血管内生物可吸收支架现状与挑战

发布时间：2018-02-20 01:07

本文关键词： 生物可吸收血管支架可降解材料动脉硬化再狭窄　出处：《中国生物医学工程学报》2017年03期 　论文类型：期刊论文

【摘要】：尽管目前介入用血管支架各类药物涂层技术较从前已经获得长足的进步,涂层支架的临床使用数量也远远超过裸支架,但远期疗效仍有待继续验证。无论何种药物涂层支架,当其被植入生物体内一段时间后,表面携带的功能药物涂层都会被生物体逐渐吸收而最终露出裸支架,带来晚期再狭窄及血栓的问题。因此,生物可吸收支架应运而生。由于其具有独特的可降解性,随着植入时间的延长而逐渐在生物体内被完全降解、吸收,最终代谢出体外;同时,血管自有的部分原始功能也得到一定恢复,如同从未被植入过支架一般。重点介绍国内外高分子聚合物、镁合金、纯铁、锌合金等几种不同材质的生物可吸收血管支架研究现状,并分析各材质可吸收支架现存的主要问题,希望对血管介入用生物可吸收支架的了解起到一定的作用。
[Abstract]:Although various drug coating techniques for interventional vascular stents have made great progress, and the clinical use of coated stents is far greater than that of bare stents, the long-term results have yet to be verified. No matter what kind of drug-coated stents, When it is implanted in the organism for a period of time, the coating of the functional drug carried on the surface is gradually absorbed by the organism and eventually exposed to the bare scaffold, causing problems of late restenosis and thrombosis. The bioabsorbable scaffold came into being. Because of its unique biodegradability, it was gradually completely degraded, absorbed and metabolized in vivo with the prolongation of implantation time; at the same time, Some of the original functions of blood vessels have also been restored, as if they had never been implanted with stents. The research status of bioabsorbable vascular stents with different materials, such as zinc alloy, is reviewed, and the main problems of bioabsorbable stents with different materials are analyzed in order to play a role in the understanding of bioabsorbable stents for vascular intervention.
【作者单位】：大连市中心医院血管外科;
【分类号】：R318.08;R654

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