Biomaterials for refractive correction:corneal onlays and in

发布时间：2018-02-26 06:21

本文关键词： refractive error onlays inlays synthetic polymer biological extracellular matrix refractive surgery　出处：《Science China(Chemistry)》2014年04期 　论文类型：期刊论文

【摘要】：Corneal inlays and onlays represent a means of providing patients with permanent refractive error correction. As an alternative to conventional spectacles and contact lens, these techniques are less invasive compared with laser-based refractive surgery and are reversible. In this review, we provide a brief overview of the anatomic microstructure of the human cornea, indicating the primary physiological function for each component. Next, the wide range of biomaterials used as corneal inlays and onlays are considered, from synthetic polymers to biological components derived from the extracellular matrix. The limitations and challenges associated with the most common materials are discussed as is the need to improve their properties to achieve long-term, complication-free intraocular implantation. Finally, the prospect of applying tissue engineering strategies is noted for its potential to generate autologous corneal tissue that could be implanted as the optimal inlay or onlay materials.
[Abstract]:Corneal inlays and onlays represent a means of providing patients with permanent refractive error correction. As an alternative to conventional spectacles and contact lens, these techniques are less invasive compared with laser-based refractive surgery and are reversible. In this review, we provide a brief overview of the anatomic microstructure of the human cornea, indicating the primary physiological function for each component. Next, the wide range of biomaterials used as corneal inlays and onlays are considered, from synthetic polymers to biological components derived from the extracellular matrix. The limitations and challenges associated with the most common materials are discussed as is the need to improve their properties to achieve long-term, complication-free intraocular implantation. Finally, the prospect of applying tissue engineering strategies is noted for its potential to generate autologous corneal tissue that could be implanted as the optimal inlay or onlay materials.
【作者单位】： McGowan
【基金】：the financial support from NIH grants(EY016415)to J.L.Funderburgh Core grant(P30-EY08098) Other support was received from the Ocular Tissue Engineering and Regenerative Ophthalmology(OTERO)program of the Louis J Fox Center for Vision Restoration the McGowan Institute for Regenerative Medicine,Research to Prevent Blindness Inc
【分类号】：R318.08;TQ317

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