物理抗菌材料防治输尿管支架管留置相关感染的临床研究

发布时间：2018-03-02 20:31

本文选题：尿路感染　切入点：有机硅季铵盐　出处：《暨南大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的:通过临床试验置入被覆物理抗菌膜的输尿管支架管，，研究物理抗菌材料防治输尿管支架管留置引起感染的作用。方法：开展临床研究60例，分为观察组和对照组两组，观察组予输尿管镜碎石术后置入物理抗菌材料组输尿管支架管。对照组置入未予特殊处理的同公司同批次输尿管支架管。比较两组患者术后导管留置相关感染临床表现以及记录两组患者术后实验室检查(尿白细胞、尿培养，CRP(C反应蛋白Creativeprotein)、PCT（降钙素原procalcitonin）比较两组间有无差别。结果：所有患者均顺利完成输尿管镜碎石术，在纳入实验组的患者中，术后3天、7天、14天、28天尿路感染的发生率分别为3.3%、6.7%、6.7%、16.7%。对照组术后3天、7天、14天、28天尿路感染的发生率分别为6.7%、20%、30%、43.3%。术后3天实验组和对照组尿路感染的发生率相差不大，而术后7天、14天、28天尿路感染发生率实验组比对照组明显低（P＜0.05）。实验组中CRP、PCT、尿白细胞计数等实验室检查在术后3天与对照组相差不大（P＜0.05），术后7天、14天、28天实验组CRP、PCT及尿中白细胞计数均比对照组低（P＜0.05）。随着输尿管支架管留置时间的延长两组尿路感染的发生率增高，对照组发病率增高趋势比试验组明显。结论:通过临床研究证实，置入经过被覆有机硅季铵盐物理抗菌材料处理的输尿管支架管，与置入未经处理的输尿管支架管对比，能够有效的避免及减轻导管留置相关感染的发生率。
[Abstract]:Objective: to study the effect of physical antimicrobial materials on ureteral stents in the treatment of ureteral stents. Methods: sixty cases of clinical study were divided into two groups: observation group and control group. The observation group was treated with ureteroscopic lithotripsy and physical antibacterial material was placed in the ureteral stent tube. The control group was treated with the same batch of ureteral stents without special treatment. The infection associated with catheter indwelling was compared between the two groups. Bed manifestations and postoperative laboratory examinations (urine leukocytes) were recorded in both groups. There was no difference between the two groups in urine culture CRP C-reactive protein and PCT (procalcitonin). Results: all patients successfully completed ureteroscopic lithotripsy. The incidence of urinary tract infection in the control group was 6.77.The incidence of urinary tract infection in the control group was 6.70.The incidence of urinary tract infection on the 3rd day, the 7th day, the 14th day, the 28th day after operation in the control group was 6.70.The incidence of urinary tract infection in the experimental group and the control group was similar to that in the control group on the 3rd day after operation. The incidence of urinary tract infection in the experimental group was significantly lower than that in the control group on the 7th and 14th day after operation (P < 0.05). The laboratory examination of CRPnPCT and urine white blood cell count in the experimental group was not significantly different from that in the control group on the 3rd day after operation (P < 0.05), and on the 14th day after operation, it was 28 days after the operation in the experimental group (P < 0.05). WBC count in urine was lower than that in control group (P < 0.05). The incidence of urinary tract infection increased with the prolongation of ureteral stent indwelling time. The increasing trend of incidence in the control group was more obvious than that in the experimental group. Conclusion: it is proved by clinical study that ureteral stents treated with organic quaternary ammonium salt and untreated ureteral stents are better than untreated ureteral stents. Can effectively avoid and reduce the incidence of catheter indwelling associated infections.
【学位授予单位】：暨南大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R318.08;R699.4

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