可降解镁基金属骨缺损修复材料的研究探索

发布时间：2018-03-06 05:02

本文选题：骨缺损　切入点：骨修复　出处：《金属学报》2017年10期 　论文类型：期刊论文

【摘要】：由于各种原因所造成的骨缺损的修复是临床上一项具有挑战的难题,理想的骨修复材料应同时具备良好的生物相容性、骨传导、骨诱导以及成骨功能。自体骨虽然被视为骨修复材料的"金标准",却存在取骨量有限和取骨区并发症等问题,而人工合成骨修复材料则还不具备骨诱导能力以及成骨性能,因此临床常用的骨移植材料以及骨移植替代材料都存在各自的应用局限。可降解镁基金属(纯Mg和镁合金)由于具有生物可降解、良好的生物相容性以及与骨组织接近的弹性模量和密度等特性受到人们的广泛关注。本文较系统地综述了镁基金属在骨填充应用研究中的生物学行为,包括良好的促成骨、骨传导能力,潜在的骨诱导作用,以及抗菌、抗肿瘤等独特的生物功能,虽然其在临床应用上仍需要继续研究探索,但不可否认其在骨缺损修复方面具有巨大的优势和潜力,有望成为新一代骨缺损修复替代材料。
[Abstract]:The repair of bone defects caused by various causes is a challenging problem in clinical practice. The ideal bone repair materials should have good biocompatibility and bone conduction at the same time. Bone induction and osteogenic function. Although autogenous bone is regarded as the "gold standard" of bone repair materials, it has problems such as limited amount of bone extraction and complications in bone extraction area, while synthetic bone repair materials do not have the ability of bone induction and osteogenesis. Therefore, the commonly used bone graft materials and bone graft replacement materials have their own limitations. Biodegradable magnesium based metals (pure mg and magnesium alloys) are biodegradable. Good biocompatibility and the properties of elastic modulus and density close to bone tissue have attracted much attention. In this paper, the biological behavior of magnesium based metal in the application of bone filling is reviewed systematically, including good bone promotion. The unique biological functions, such as bone conduction ability, potential bone inducement, antibacterial and anti-tumor, need to be further studied and explored in clinical application, but it is undeniable that it has great advantages and potential in repairing bone defect. It is expected to be a new generation of bone defect replacement material.
【作者单位】：中国科学院金属研究所;中国科学技术大学材料科学与工程学院;
【基金】：国家自然科学基金项目Nos.81401773和31500777~~
【分类号】：R318.08;TG146.22

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