聚对苯二甲酸乙二醇酯人工韧带支架材料的空穿编织和力学性能分析

发布时间：2018-03-09 09:21

本文选题：聚对苯二甲酸乙二醇酯　切入点：空穿编织　出处：《第四军医大学》2012年硕士论文　论文类型：学位论文

【摘要】：背景：随着国力的发展壮大以及生活水平的提高，体育运动逐渐普及，而关节韧带的损伤发生率也逐年增高，保守估计每年韧带损伤的患者应不下1千万例。人体的韧带组织与骨组织不同，发生损伤断裂后定然无法自然愈合而必须进行早期修复，，这种损伤若不加处理通常会降低关节稳定性和继发其他组织结构损伤，并最终导致严重的相关关节运动功能障碍。已发明并投入使用的韧带重建方法有很多，得到广泛共识的是自体或异体肌腱移植重建，但是包括髌腱/乆绳肌的自体肌腱移植可能会引起相关肌腱供区的继发疾病，包括会引起供区髌腱炎、肌力减退和髌下脂肪垫挛缩；异体肌腱又存在长入延迟、术后移植物强度减弱、引发免疫排斥反应和传播感染性疾病的风险，所以自体或异体肌腱移植带来的并发症几乎是不可避免的。近年来，国外的外科医生普遍认同采用人工韧带移植重建来恢复关节运动功能，它已成为应对关节损伤的常规手术，而目前国内医疗市场的人工韧带医疗产品均无自主知识产权；通过回顾文献，我们还发现国外现有的同类医疗产品生物相容性较差，仍达不到完美的效果。聚对苯二甲酸乙二醇酯(Polyethylene terephthalate, PET)作为聚酯的代表，完全能满足人体天然韧带的力学要求，我们拟通过编织PET纤维构建韧带支架材料，并分析支架材料力学性能，探讨使用该材料构建人工前交叉韧带支架材料的可行性。实验一聚对苯二甲酸乙二醇酯支架材料的空穿编织目的：通过对聚对苯二甲酸乙二醇酯(Polyethylene terephthalate, PET)材料的编织，构建组织工程韧带支架材料。方法：使用RSJ4型多梳花边经编机将不同强度的PET单纤维通过经编法编织，电镜观察其内部结构。结果：PET编织构建的支架材料结构稳定，适合构建人工韧带。结论：该支架材料编织结构设计合理，符合人工韧带支架材料的设计要求。实验二人工韧带支架材料的力学性能评价目的：通过对聚对苯二甲酸乙二醇酯(Polyethylene terephthalate, PET)材料的力学性能的分析，初步探讨使用该材料构建组织工程韧带支架的可行性。方法：使用电子拉力机（H25KS-S, Hounsfield Test Equipment Ltd, UK）对编织好的支架材料以及消毒处理后的支架材料进行力学性能测试并进行分析。结果：其极限抗张强度等力学指标已满足了正常人体ACL的生物力学要求。而常规辐照消毒对此支架材料的力学性能无短期影响。结论：该支架材料具有优良的力学性能，消毒后对其力学性能无短期影响，有望通过改进生物学性能后成为一种较理想的组织工程前交叉韧带支架材料。
[Abstract]:Background: with the development of national strength and the improvement of living standards, sports are becoming more and more popular, and the incidence of joint ligament injury is increasing year by year. It is conservatively estimated that there should be no less than 10 million cases of ligament injury every year. The ligament tissue of the human body is different from the bone tissue. This injury, if left untreated, usually reduces joint stability and secondary damage to other tissue structures, and ultimately leads to serious associated joint motion disorders. There are many methods of ligament reconstruction that have been invented and put into use. There is widespread consensus that autogenous or allogeneic tendon transplants can be reconstructed, but autogenous tendon transplants that include patellar / human hamstring may cause secondary diseases in the associated tendon donor area, including patellar tendinitis in the donor region. Hypotonia and subpatellar fat pad contracture, allogeneic tendon growth delayed, graft strength weakened, immune rejection and the risk of transmission of infectious diseases, In recent years, surgeons abroad generally agree that artificial ligament transplantation is widely used to restore joint motor function, which has become a routine operation to deal with joint injury. At present, the artificial ligament medical products in the domestic medical market do not have independent intellectual property rights. By reviewing the literature, we also find that the biocompatibility of similar medical products in foreign countries is poor. Polyethylene terephthalate (pet), as the representative of polyester, can completely meet the mechanical requirements of human natural ligaments. We intend to construct ligament scaffolds by weaving PET fibers. The mechanical properties of the scaffold were analyzed and the feasibility of using the material to construct the artificial anterior cruciate ligament scaffold was discussed. Experiment 1. Air penetration braiding of polyethylene terephthalate scaffold material. Objective: to construct tissue engineering ligament scaffold material by braiding polyethylene terephthalate (pet) material. Methods: PET single fiber with different strength was woven by warp knitting machine of RSJ4 type multi-comb lace. Results the structure of the scaffold was stable and suitable for the construction of artificial ligament. Conclusion: the braided structure of the scaffold is reasonable and meets the design requirements of artificial ligament scaffold. Evaluation of mechanical properties of artificial ligament scaffold in experiment 2. Objective: to analyze the mechanical properties of polyethylene terephthalate (PET). The feasibility of using this material to construct tissue engineering ligament scaffold was preliminarily discussed. Methods: the mechanical properties of woven scaffold and sterilized scaffold materials were tested by using electronic drawing machine H25KS-S, Hounsfield Test Equipment Ltd. Results: the mechanical indexes such as ultimate tensile strength have met the biomechanical requirements of ACL in normal human body, but routine irradiation disinfection has no short-term effect on the mechanical properties of the scaffold. Conclusion: the scaffold material has a short term effect. With excellent mechanical properties, There is no short-term effect on mechanical properties after disinfection. It is expected to become an ideal scaffold material for anterior cruciate ligament (ACL) by improving biological properties.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08

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