氧化钛和氧化铝陶瓷的骨诱导作用

发布时间：2018-03-13 14:42

本文选题：TiO陶瓷　切入点：AlO陶瓷　出处：《功能材料》2017年01期 　论文类型：期刊论文

【摘要】：蛋白质吸附、钙磷离子释放和表面生物矿化是钙磷材料诱导异位骨生成的可能材料机制。对比了非表面微孔羟基磷灰石陶瓷(HA-S)、表面微孔羟基磷灰石陶瓷(HA-R)和表面微孔生物惰性非钙磷陶瓷(TiO_2陶瓷;Al_2O_3陶瓷;两者无钙磷释放,无表面生物矿化能力)的异位骨诱导能力。研究发现,不同化学成分的陶瓷材料对蛋白质有选择性吸附。即使不吸附骨形态发生蛋白-2(rhBMP-2),具有表面微孔的非钙磷陶瓷也能诱导异位骨组织生成。结果表明,钙磷离子释放和表面生物矿化在磷酸钙生物材料骨诱导中不起关键作用,表面微孔也不一定通过蛋白质吸附而在异位骨诱导中起作用。
[Abstract]:Protein adsorption, Calcium and phosphorus ion release and surface biomineralization are the possible material mechanisms of heterotopic bone formation induced by calcium and phosphorus materials. A comparison between the nonsurface microporous hydroxyapatite ceramics (HA-S), the surface microporous hydroxyapatite ceramics (HA-R) and the surface microporous bioinertia was made. Non calcium phosphorus ceramics TiO2 ceramics Al2O3 ceramics; The ability of both to induce ectopic bone without calcium and phosphorus release and surface biomineralization. Protein was selectively adsorbed by ceramic materials with different chemical composition. Even if bone morphogenetic protein -2hBMP-2n was not adsorbed, non-calcium phosphate ceramics with microporous surface could induce ectopic bone tissue formation. Calcium phosphate ion release and surface biomineralization do not play a key role in bone induction of calcium phosphate biomaterials, and surface micropores do not necessarily play a role in heterotopic bone induction through protein adsorption.
【作者单位】：四川大学物理科学与技术学院生物材料研究组;Department
【基金】：国家国际科技合作专项资助项目(2013DFB50280)
【分类号】：R318.08

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