组织工程平滑肌构建的研究进展

发布时间：2018-03-14 23:32

本文选题：平滑肌细胞　切入点：干细胞　出处：《中国生物医学工程学报》2014年01期 　论文类型：期刊论文

【摘要】：平滑肌在人和动物体内分布广泛,普遍存在于消化道、呼吸道、血管、泌尿、生殖等诸多内脏器官中,通过收缩蠕动来协助器官的功能发挥,是重要的功能组织。平滑肌组织工程的研究目的就是要为这些组织和器官的功能化重建提供支撑。目前关于单纯平滑肌组织工程研究的报道并不太多,大多的研究主要结合在诸如血管、胃肠等组织/器官的构建中。对于平滑肌的构建仍然存在诸如生物材料的性能不可控、支架的制备技术较单一、种子细胞的培养技术和生物功能较欠缺、以及动物体内实验不完善等问题,实验室研究与实际应用还存在较大距离。本文主要从种子细胞的获取及支架构建两大方面阐述平滑肌组织工程的研究进展。从干细胞诱导分化为平滑肌细胞的研究示例中展望干细胞作为种子细胞的前景。
[Abstract]:Smooth muscle is widely distributed in humans and animals. It is found in many visceral organs, such as digestive tract, respiratory tract, blood vessel, urinary tract, reproduction and so on. It helps the function of organs by contractile peristalsis. The purpose of smooth muscle tissue engineering is to provide support for the functional reconstruction of these tissues and organs. At present, there are not many reports on pure smooth muscle tissue engineering. Most of the research is mainly combined with the construction of tissues / organs such as blood vessels and gastrointestinal tract. For the construction of smooth muscle, such as the performance of biomaterials is not controllable, the scaffold preparation technology is relatively simple. The culture technology and biological function of seed cells are deficient, and the experiments in animals are not perfect. There is still a long way between laboratory research and practical application. In this paper, the progress of smooth muscle tissue engineering is described from two aspects: seed cell acquisition and scaffold construction. Differentiation from stem cells to smooth muscle cells. The future of stem cells as seed cells is prospected in the example.
【作者单位】：浙江省宁波大学医学院;
【基金】：国家自然科学基金(81171476) 浙江省杰出青年科学基金(R2101166) 宁波市创新团队基金(2011B82014)
【分类号】：R318.08

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