药物洗脱支架植入病灶部位后的血流特性

发布时间：2018-03-18 14:45

本文选题：支架内再狭窄　切入点：裸金属支架　出处：《医用生物力学》2014年04期 　论文类型：期刊论文

【摘要】：目的研究冠脉内植入药物释放支架后的血液流动特性,为临床应用及改善药物洗脱支架的设计提供理论指导。方法建立病灶部位植入药物洗脱支架后的数值模型,利用计算流体动力学方法进行药物浓度分布及壁面剪切力分布的数值分析研究,并将计算结果与裸金属支架植入后的计算结果进行比较。结果药物洗脱支架在血流过程中产生的低壁面剪切力区域几乎都伴随着较高的药物浓度分布,而低药物浓度区域则伴随的是较高的壁面剪切力分布,显著地减少了低壁面剪切力区域或低药物浓度区域独立存在的区域。理论上,药物释放支架在药物释放阶段比植入裸金属支架具有优越性。结论药物洗脱支架能够显著降低支架内的再狭窄率。详细了解药物洗脱支架的流场分布规律将有利于改善药物洗脱支架的设计,进一步提高支架的整体性能,为临床应用提供理论依据。
[Abstract]:Objective to study the characteristics of blood flow after drug release stent implantation in coronary artery, and to provide theoretical guidance for clinical application and improvement of drug eluting stent design. The distribution of drug concentration and wall shear force was studied by using the computational fluid dynamics (CFD) method. The calculated results were compared with those after bare metal stent implantation. Results the low wall shear stress of drug-eluting stents in the blood flow process was almost accompanied by higher drug concentration distribution. However, the low drug concentration region is accompanied by higher wall shear stress distribution, which significantly reduces the low wall shear stress region or the independent region of low drug concentration region. Conclusion Drug-eluting stents can significantly reduce the restenosis rate of stents. A detailed understanding of the flow field distribution of drug-eluting stents will be beneficial. To improve the design of drug-eluting stents, Further improve the overall performance of the stent and provide a theoretical basis for clinical application.
【作者单位】：西安交通大学机械工程学院机械制造系统工程国家重点实验室;
【基金】：国家自然科学基金资助项目(50775179)
【分类号】：R318.08

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