吻合器作用下小肠组织细胞内外液变化研究

发布时间：2018-03-19 14:57

本文选题：吻合器　切入点：压榨　出处：《中国生物医学工程学报》2017年01期 　论文类型：期刊论文

【摘要】：明确胃肠组织在吻合器作用下的内部变化情况是吻合器工程参数优化的前提。改造直线型吻合器,嵌入检测电极;测量猪小肠在吻合器压榨作用下的多频生物阻抗,使用ColeY模型对测量结果拟合,模型参数G_0、ΔG表征细胞外液、内液电导;改变垫片厚度,得到不同压榨强度下G_0和ΔG的变化曲线。压榨过程分为两个阶段:第1个阶段,两个参数都迅速下降;第2个阶段,随着压榨强度的增加,G_0始终保持减小趋势,ΔG由轻微波动变为轻微下降;当垫片厚度从0 mm增加至0.52 mm,ΔG和承受压强之间具有显著极相关性的样本数占总样本数的比例从40%上升至100%,而对于G_0,这个比例始终为100%。结果表明:小肠在吻合器作用下,有部分组织被挤压出测量空间,引起参数迅速下降;而后,吻合器持续压榨组织,细胞外液持续排出,细胞内液在不同压榨强度下表现出不同趋势,可能和细胞的受压形变有关。该研究可为吻合器参数优化提供条件。
[Abstract]:The internal changes of gastrointestinal tissue under the action of stapler are the premise of optimizing the engineering parameters of stapler. The linear stapler is modified, the detection electrode is embedded, and the multifrequency biological impedance of pig small intestine is measured under the pressure of stapler. The ColeY model was used to fit the measurement results. The model parameters G _ 0, 螖 G were used to characterize the extracellular fluid and internal fluid conductance, and to change the thickness of gasket, the curves of G _ 0 and 螖 G were obtained under different press intensity. The pressing process was divided into two stages: the first stage. In the second stage, with the increase of squeezing intensity, G _ 0 kept decreasing, and 螖 _ G changed from slight fluctuation to slight decrease. When the thickness of gasket increased from 0 mm to 0 52 mm, the proportion of samples with significant correlation between 螖 G and pressure increased from 40% to 100mm, and for Gal 0, the ratio was always 100mm. The results showed that the small intestine was under the action of stapler. Some of the tissues were squeezed out of the measurement space, resulting in a rapid decline in parameters; then, the stapler continued to press the tissue, the extracellular fluid continued to drain, and the intracellular fluid showed different trends at different press intensities. It may be related to the deformation of cells under compression. This study can provide conditions for parameter optimization of stapler.
【作者单位】：上海理工大学医疗器械与食品学院;
【基金】：国家自然科学基金(51377024) 上海市自然科学基金(14ZR1428300)
【分类号】：R318.6

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