生物陶瓷在骨组织工程中的应用进展

发布时间：2018-03-19 17:01

本文选题：牙瓷料　切入点：磷灰石　出处：《中国组织工程研究》2017年22期 　论文类型：期刊论文

【摘要】：背景:生物陶瓷与正常人体骨组织组成相似,具有良好的骨诱导骨传导活性及生物相容性,因此被认为是骨组织工程最有运用前景的材料之一。目的:总结生物陶瓷材料的各种性能、实验研究及临床应用进展。方法:以"bioceramics,hydroxylapatite,calcium phosphate,bioglass,bone tissue engineering"为检索词,应用计算机检索Pub Med数据库2000至2016年的相关文献。结果与结论:生物陶瓷材料可分为钙磷灰石类和生物活性玻璃两大类,钙磷灰石类材料具有良好的生物相容性和骨诱导活性,但机械强度较差;生物活性玻璃材料也具有良好的生物相容性且有助于部分成骨基因的表达,但脆性较大、强度不足。部分生物陶瓷材料作为支架主体已在临床上应用,近年来,钙磷灰石类材料也用作骨组织工程支架涂层材料改善支架各项性能。将生物陶瓷材料与高分子材料复合,可提高生物陶瓷材料的强度,改善其降解活性,但其作为骨组织修复材料被广泛用于临床仍面临许多问题与挑战。
[Abstract]:Background: bioceramics have good bone conduction activity and biocompatibility similar to those of normal human bone tissue. Therefore, it is considered as one of the most promising biomaterials in bone tissue engineering. Objective: to summarize the properties, experimental research and clinical application of bioceramics. Methods: "bioceramics hydroxylapatite calcium phosphate bioglassbone tissue engineering" was used as the key word. Results and conclusion: bioceramic materials can be classified into two categories: calcium apatite and bioactive glass. Calcium apatite has good biocompatibility and bone inductive activity. But the mechanical strength is poor, the bioactive glass material also has good biocompatibility and is helpful for the expression of some osteogenic genes, but the brittleness is large, the strength is insufficient. Some bioceramic materials have been used in clinic as the main body of the scaffold. In recent years, calcium apatite materials have also been used as scaffold coating materials for bone tissue engineering to improve the properties of scaffolds. Combining bioceramic materials with polymer materials can improve the strength and degradation activity of bioceramic materials. However, it still faces many problems and challenges as bone tissue repair materials are widely used in clinic.
【作者单位】：上海市第九人民医院口腔颅颌面科;
【分类号】：R318.08;R68

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