MG53蛋白对器官缺血再灌注损伤保护作用的现在与未来

发布时间：2018-03-21 19:30

本文选题：肌　切入点：血管　出处：《中国组织工程研究》2017年20期 　论文类型：期刊论文

【摘要】：背景:近年来随着休克治疗的进步以及动脉搭桥术、溶栓疗法、经皮腔内冠状动脉成形术、心脏外科体外循环、心肺脑复苏,断肢再植和器官移植等方法的建立和推广应用,多种器官缺血后重新得到血液再灌注。但缺血一定时间的器官重新恢复血液供应后,会出现损伤加重的表现。目的:总结MG53蛋白在5种器官缺血再灌注损伤保护中的研究和进展,并为其进一步研究提供有益的参考。方法:应用计算机检索1986至2016年Pub Med、读秀学术搜索和CNKI数据库相关文章,英文检索词为"MG53,TRIM,Mitsugumin53,ischemic,reperfusion,Preconditioning,Preconditioning,RISK,membrane damage,Connexin43,KCh IP2",中文检索词为"MG53蛋白,缺血再灌注"。根据纳入与排除标准,最终保留61篇文献进行综述。结果与结论:(1)内源性MG53蛋白作为一种肌特异性膜修复蛋白,能参与肌细胞膜损伤修复作用和缺血预适应、缺血后适应保护作用;(2)外源性重组人MG53蛋白不仅对多种肌和非肌细胞膜损伤发挥修复作用,而且对心肌、骨骼肌、脑、肺脏和肾脏在内的多种器官缺血再灌注损伤还具有保护作用。
[Abstract]:Background: with the development of shock therapy and the establishment and application of arterial bypass grafting, thrombolytic therapy, percutaneous transluminal coronary angioplasty, cardiopulmonary bypass, cardiopulmonary resuscitation, amputated limb replantation and organ transplantation, etc. After ischemia, many organs get blood reperfusion again. However, after a certain period of ischemia, the organs are restored to blood supply. Objective: to summarize the research and progress of MG53 protein in the protection of 5 kinds of organ ischemia-reperfusion injury. Methods: using computer to search Pub Medfrom 1986 to 2016, reading articles related to academic search and CNKI database, the English key words were: "MG53 / Mitsugumin53" in English: "MG53 / Mitsugumin53" in English: "MG53" in English: "MG53" in English: "MG53" in English: "MG53" in English and "MG53 protein in Chinese" in the following words: "MG53", "MG53", "Mitsugumin53" and "MG53 protein" in Chinese, "MG53", "MG53", "Mitsuguminum53" and "MG53 protein" in Chinese. According to the criteria of inclusion and exclusion, 61 articles were reviewed. Results and conclusions the endogenous MG53 protein, as a kind of muscle-specific membrane repair protein, can participate in the repair of myocyte membrane damage and ischemic preconditioning. The exogenous recombinant human MG53 protein not only repair the membrane damage of many kinds of muscle and non-muscle, but also the myocardium, skeletal muscle and brain. Many organs, including lung and kidney, also have protective effects on ischemia-reperfusion injury.
【作者单位】：郑州大学生命科学学院;郑州大学第一附属医院;
【基金】：国家自然科学基金资助项目(81601078,81471306) 河南省高校科技创新团队(15IRTSTHN022) 河南省科技创新人才计划(154200510008) 河南省国际人才合作项目(2016GH03,2016GH15)~~
【分类号】：R318

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