激光熔覆技术制备的纳米钽-钛合金棒结构特征及生物相容性

发布时间：2018-04-03 22:43

本文选题：纳米钽　切入点：多孔　出处：《南方医科大学学报》2014年06期

【摘要】：目的运用激光熔覆技术制备新型纳米钽-钛合金棒并研究其结构特征及生物相容性,为临床选用内固定提供依据。方法以纳米级钽粉(Ta,Tantalum)为原料,利用激光熔覆技术制备两侧具有对称纳米钽涂层的新型钛合金棒。SEM观察微观界面结构、测量孔隙直径并分析金相成分。采用MTT细胞毒性试验和ALP活性检测评价新型纳米钽-钛合金对MC3T3-E1细胞增殖和分化性能的影响。结果扫描电镜下观察到试样的Ta涂层表面呈粗糙多孔结构,钽粉颗粒间致密熔融,孔隙直径平均在200~300μm之间,加工过程前后成分一致;成分分析结果显示熔覆过程并未产生新的元素。两组材料皆可明显促进MC3T3-E1细胞增值,但新型纳米钽-钛合金性能更为优异,同时能够促进成骨细胞的骨化,差异具有统计学意义。结论激光熔覆技术可成功实现钽与医用钛合金的冶金结合,并使其拥有良好的表面结构和生物相容性。
[Abstract]:Objective to prepare new nano tantalum-titanium alloy rod by laser cladding and to study its structure and biocompatibility so as to provide evidence for clinical selection of internal fixation.Methods A new titanium alloy rod with symmetrical nano-tantalum coating on both sides was prepared by laser cladding technique. The microstructure of the interface was observed, pore diameter was measured and metallographic composition was analyzed.MTT cytotoxicity test and ALP activity test were used to evaluate the effect of new nano tantalum titanium alloy on proliferation and differentiation of MC3T3-E1 cells.Results under scanning electron microscope, the surface of Ta coating showed rough porous structure, dense melt between tantalum powder particles, the average pore diameter was between 200 ~ 300 渭 m, and the composition of Ta coating was the same before and after processing.The results of composition analysis showed that no new elements were produced in the cladding process.Two groups of materials can obviously promote the proliferation of MC3T3-E1 cells, but the new nano-tantalum titanium alloy has better properties and can promote osteoblast ossification, the difference is statistically significant.Conclusion the laser cladding technique can successfully realize the metallurgical bonding of tantalum with medical titanium alloy and make it have good surface structure and biocompatibility.
【作者单位】：南方医科大学南方医院脊柱骨科;苏州大学激光加工中心;
【基金】：国家自然科学基金(81272022) 南方医科大学南方医院2010年度院长基金(2010A002)~~
【分类号】：R318.08

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